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Titolo:
A bivariate Haseman-Elston method and application to the analysis of asthma-related phenotypes on chromosome 5q
Autore:
Ziegler, A; Boddeker, IR; Geller, F;
Indirizzi:
Univ Marburg, Inst Med Biometry & Epidemiol, Med Ctr Methodol & Hlth Res, D-35003 Marburg, Germany Univ Marburg Marburg Germany D-35003 Hlth Res, D-35003 Marburg, Germany
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S216 - S221
SICI:
0741-0395(2001)21:<S216:ABHMAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAITS; LINKAGE; PEDIGREES;
Keywords:
model-free linkage analysis; multivariate phenotype; multiple sibships;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, A Univ Marburg, Inst Med Biometry & Epidemiol, Med Ctr Methodol &Hlth Res, Bunsenstr 3, D-35003 Marburg, Germany Univ Marburg Bunsenstr 3 Marburg Germany D-35003 burg, Germany
Citazione:
A. Ziegler et al., "A bivariate Haseman-Elston method and application to the analysis of asthma-related phenotypes on chromosome 5q", GENET EPID, 21, 2001, pp. S216-S221

Abstract

We propose a bivariate combination of different Haseman-Elston (HE) methods for model free linkage analysis of quantitative traits. Adjustments for correlations of phenotypes and sibship sizes > 2 are performed using generalized estimating equations (GEE). All calculations are carried out with freely available software packages. We illustrate the application of standard HE methods, the unified HE method, and our novel approach to asthma-associated quantitative traits from the COAG-Perth data set [Palmer et al., 1998, Am J Respir Crit Care Med 158:1825-30]. Our multipoint analyses provide evidence for linkage between log IgE levels adjusted for age, gender and antigen-specific IgE titers. Our results are consistent with previous findings that suggest the existence of loci regulating asthma-associated quantitative traits in the 5q31-33 chromosomal region. Simulation studies are required to compare the power of our novel bivariate HE with other HE approaches and the variance component method. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 05:42:51