Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma
Autore:
Bethony, J; Williams, JT; Almasy, L; Correa-Oliveira, R; Blangero, JC; Williams-Blangero, S;
Indirizzi:
Fiocruz MS, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG, Brazil Fiocruz MS Belo Horizonte MG Brazil BR-30190002 BCo Horizonte, MG, Brazil SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA SW Fdn Biomed Res San Antonio TX USA es, Dept Genet, San Antonio, TX USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S174 - S179
SICI:
0741-0395(2001)21:<S174:GAOQTI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE ANALYSIS; PEDIGREES; MODELS; LOCI;
Keywords:
ascertainment asthma; immunoglobulin E (IgE); statistical genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Bethony, J Fiocruz MS, Ctr Pesquisas Rene Rachou, Av Augusto de Lima 1715,BR-30190002 Belo Horizonte, MG, Brazil Fiocruz MS Av Augusto de Lima 1715 Belo Horizonte MG Brazil BR-30190002 BC
Citazione:
J. Bethony et al., "Genetic analysis of quantitative traits in highly ascertained samples: Total serum IgE in families with asthma", GENET EPID, 21, 2001, pp. S174-S179

Abstract

The objective of this study was to compare the effect of an approximate ascertainment correction using proband phenotypes with heuristic corrections based on sample trait means and on published "standard" population values. Data were from the Collaborative Study on the Genetics of Asthma, which comprises 225 families ascertained through sib pairs affected with asthma. In variance component linkage analysis of IgE no lod scores greater than 3.0 were observed, either with or without several attempted corrections for ascertainment, The ascertained nature of the sample may have compromised the power to detect linkage to a quantitative trait (IgE) associated with the focal phenotype (asthma). (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 08:37:56