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Titolo:
Structure, promoter and chromosomal localization of rdh6
Autore:
Chai, XY; Chen, WG; Napoli, JL;
Indirizzi:
Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Toxicol, Berkeley, CA 94720 USA
Titolo Testata:
GENE
fascicolo: 1-2, volume: 274, anno: 2001,
pagine: 27 - 33
SICI:
0378-1119(20010822)274:1-2<27:SPACLO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
11-CIS RETINOL DEHYDROGENASE; SHORT-CHAIN DEHYDROGENASE; GENE STRUCTURE; CDNA CLONING; MESSENGER-RNA; EXPRESSION; TISSUE; ISOZYME; ACID; IDENTIFICATION;
Keywords:
retinol; retinal; retinoids; short-chain dehydrogenase/reductase; hydroxysteroid dehydrogenase; cis-retinoid/androgen dehydrogenase type 1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Napoli, JL Univ Calif Berkeley, Dept Nutr Sci & Toxicol, 119 Morgan Hall,MC 3104, Berkeley, CA 94720 USA Univ Calif Berkeley 119 Morgan Hall,MC 3104 Berkeley CA USA 94720
Citazione:
X.Y. Chai et al., "Structure, promoter and chromosomal localization of rdh6", GENE, 274(1-2), 2001, pp. 27-33

Abstract

Mouse rdh6 encodes cis-retinoid/androgen dehydrogenase type 1 (CRAD1), a short-chain dehydrogenase, which recognizes as substrates 9-cis-retinol, 11-cis-retinol, 5 alpha -androstan-3 alpha, 17 beta -diol and 5 alpha -androstan-3 alpha -ol-17-one, and is expressed most intensely in liver and kidney. The present study reports the genomic organization, chromosomal localization and promoter region sequence of rdh6. Rdh6 spans more than 38 kb and consists of four exons ranging from 164 to 2200 bp, and three introns ranging from 550 bp to greater than 18 kb. The gene localizes to the distal end of mouse chromosome 10, 72.5 cM from the centromere, and colocalizes with mouse rdh7, which encodes CRAD2. This corresponds to the locus of human rdh5 onhuman chromosome 12. Primer extension assays indicate two major transcription start sites in liver and one in kidney. The similar to 2000 kb sequenced of the 5'-flanking region contains multiple potential transcription factor binding sites, including sites for AP-1, C/EBP beta, GATA, c-Rel, ER, RORalpha, SREBP, and CREB. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:20:18