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Titolo:
Transduction pathways involved in hypoxia-inducible FACTOR-1 phosphorylation and activation
Autore:
Minet, E; Michel, G; Mottet, D; Raes, M; Michiels, C;
Indirizzi:
Fac Univ Notre Dame Paix, Lab Biochim & Biol Cellulaire, B-5000 Namur, Belgium Fac Univ Notre Dame Paix Namur Belgium B-5000 ire, B-5000 Namur, Belgium
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 7, volume: 31, anno: 2001,
pagine: 847 - 855
SICI:
0891-5849(20011001)31:7<847:TPIIHF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; UBIQUITIN-PROTEASOME PATHWAY; FACTOR 1-ALPHA HIF-1-ALPHA; TYROSINE-HYDROXYLASE GENE; DELAYED NEURONAL DEATH; DNA-BINDING ACTIVITY; C-FOS TRANSCRIPTION; SMOOTH-MUSCLE CELLS; PROTEIN-KINASE; TUMOR ANGIOGENESIS;
Keywords:
hypoxia; hypoxia-inducible factor-1; mitogen-activated protein kinases; phosphoinositide-3 kinase; signaling; tumorigenesis; free radicals;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Michiels, C Fac Univ Notre Dame Paix, Lab Biochim & Biol Cellulaire, 61 Rue Bruxelles,B-5000 Namur, Belgium Fac Univ Notre Dame Paix 61 Rue BruxellesNamur Belgium B-5000
Citazione:
E. Minet et al., "Transduction pathways involved in hypoxia-inducible FACTOR-1 phosphorylation and activation", FREE RAD B, 31(7), 2001, pp. 847-855

Abstract

Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress, HIF-1 triggers the overexpression of genes coding for glycolytic enzymes and angiogenic factors. To be active HIF-1 must be phosphorylated. HIF-1 is a substrate for various kinase pathways including PI-3K and the MAP kinases ERK and p38. Several transduction pathways have been proposed which act downstream of putative oxygen sensors and lead to the activation of these kinases. In this review, we summarize some of the latest advances describing the possible signaling pathways leading to HIF-1 phosphorylation and subsequent activation. The physiological relevance of these regulations is also discussed. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:03