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Titolo:
On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors
Autore:
Pollmacher, T; Schuld, A; Kraus, T; Haack, M; Hinze-Selch, D;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Univ Kiel, Klin Psychiat & Psychotherapie, Kiel, Germany Univ Kiel Kiel Germany l, Klin Psychiat & Psychotherapie, Kiel, Germany
Titolo Testata:
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
, volume: 69, anno: 2001, supplemento:, 2
pagine: S65 - S74
SICI:
0720-4299(200109)69:<S65:OTCROC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
GER
Soggetto:
TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; DIABETIC-KETOACIDOSIS; PLASMA-LEVELS; INDUCED AGRANULOCYTOSIS; ANTIPSYCHOTIC-DRUGS; SCHIZOPHRENIC-PATIENTS; TOXIC HEPATITIS; FACTOR-ALPHA; WEIGHT-GAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
T. Pollmacher et al., "On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors", F NEUR PSYC, 69, 2001, pp. S65-S74

Abstract

Cytokines are pivotal mediators of the interaction between immunocompetentcells. Moreover, they mediate the interaction between the immune system and other physiological systems, including the CNS. It has been shown recently that the antipsychotic drug clozapine stimulates in vivo the release of cytokines and soluble cytokine receptors. This holds true for the tumor necrosis factor(TNF)-system, the interleukin(IL)-2-system, IL-6, and granulocyte colony-stimulating factor (G-CSF). The present paper discusses the clinical relevance of these findings for the pathophysiology of clozapine-inducedside-effects. It is very probable that TNF-alpha plays an important role in clozapin-induced fever and in the hematopoetic side effects, including agranulocytosis. Moreover, it is likely that TNF-alpha and other cytokines are involved in metabolic (weight gain, diabetes), cardiac (myocarditis), CNS(sedation) and other rare side effects. The mechanisms underlying clozapine-induced immunomodulation are unknown. Hence, further studies are very important to enhance our understanding of clozapins's side effects and to develop strategies for prevention and treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:36:34