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Titolo:
Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies
Autore:
Ho, HN; Chao, KH; Chen, HF; Chen, SU; Wu, MY; Yang, YS;
Indirizzi:
Natl Taiwan Univ, Coll Med & Hosp, Dept Obstet & Gynecol, Taipei 10764, Taiwan Natl Taiwan Univ Taipei Taiwan 10764 tet & Gynecol, Taipei 10764, Taiwan
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 4, volume: 76, anno: 2001,
pagine: 797 - 803
SICI:
0015-0282(200110)76:4<797:DOTATC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT SPONTANEOUS-ABORTION; LYMPHOKINE PRODUCTION; IL-10 PRODUCTION; LYMPHOCYTES; CYTOKINES; TROPHOBLAST; WOMEN; GAMMA; INTERFACE; SECRETION;
Keywords:
deciduae; flow cytometry; intracytoplasmic cytokines; Th1; Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Ho, HN Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, 7 Chung Shan South Rd, Taipei 10016, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan South Rd Taipei Taiwan 10016 an
Citazione:
H.N. Ho et al., "Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies", FERT STERIL, 76(4), 2001, pp. 797-803

Abstract

Objective: To examine whether maternal immune responses during normal pregnancy are Th2 biased and whether there are specific changes when anembryonic pregnancy occurs. Design: Prospective study. Setting: Department of Obstetrics and Gynecology at a university hospital. Patient(s): We studied 32 pregnant women receiving elective abortions of normal pregnancies and 35 women with anembryonic pregnancies between 6 weeksand 10 weeks of gestational age. Intervention(s): Using the multilabeling capability of three-color flow cytometry, it is possible to measure intracellular cytokines and cell surfacemarkers simultaneously to determine which cells are the cytokine-producingcells. Main Outcome Measure(s): We examined the extent and proportion of mononuclear cells expressing specific T-cell surface markers and cytokines, interferon gamma, and interleukin 4 in the peripheral blood and deciduae. Secretedcytokines in the supernatants after 24-hour culture were also compared. Result(s): During the unstimulated status, the proportion of IL-4-secreting cells significantly exceeded that of IFN-gamma -secreting cells in the peripheral blood and decidua in normal pregnancies and was significantly decreased when anembryonic pregnancies occurred. Consequently, the Th1/Th2 ratios were increased during anembryonic pregnancies. However, after 24-hour culture, only another Th2-type cytokine, IL-10, was markedly increased and exceeded IFN-gamma secretion in cultures from both the peripheral blood and decidua in normal pregnancies. Conclusion(s): The decidual T lymphocytes are Th2 predominant. When anembryonic pregnancy occurs, this Th2 predominance disappears. (Fertil Steril(R)2001;76:797-803. (C) 2001 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:02:41