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Titolo:
Eletriptan
Autore:
Grujich, NN; Gawel, MJ;
Indirizzi:
Univ Toronto, Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Neurol, Toronto,ON, Canada Univ Toronto Toronto ON Canada h Sci Ctr, Div Neurol, Toronto,ON, Canada
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 10, volume: 10, anno: 2001,
pagine: 1869 - 1874
SICI:
1354-3784(200110)10:10<1869:E>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-TRIAL EXPERIENCE; SUMATRIPTAN 50-100 MG; ORAL ELETRIPTAN; HEADACHE RECURRENCE; ACUTE MIGRAINE; 40-80 MG; RECEPTOR; AGONIST; NARATRIPTAN; ABSORPTION;
Keywords:
acute therapy; eletriptan; headache; migraine; symptomatic treatment; triptans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Gawel, MJ Univ Toronto, Sunnybrook & Womens Coll, Hlth Sci Ctr, Div Neurol, 100 CollSt, Toronto, ON, Canada Univ Toronto 100 Coll St Toronto ON Canada Toronto, ON, Canada
Citazione:
N.N. Grujich e M.J. Gawel, "Eletriptan", EXPERT OP I, 10(10), 2001, pp. 1869-1874

Abstract

Eletriptan (Relpax((R)), Pfizer) is one of a group of anti-migraine medications commonly referred to as 'triptans'. It is a potent serotonin agonist at the 5-HT1B/1D receptor and is indicated for the acute treatment of migraine headaches. Eletriptan is administered orally. It is rapidly absorbed and has a bioavailability of 50% compared to 14% for sumatriptan. The relatively high lipophilicity of eletriptan compared to sumatriptan may explain its faster oral absorption and shorter time: to onset of action. Results fromcomparative studies between oral eletriptan and sumatriptan indicate that eletriptan 80 mg was superior to sumatriptan 100 mg in onset of action, headache response rate, pain free response rate and relief of associated migraine symptoms at the 1 or 2 h time intervals. Although there was a modest increase in adverse events with eletriptan 80 mg than with sumatriptan 100 mg, eletriptan received a high patient acceptability rating (84%) [4].

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 03:59:09