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Titolo:
Antiglucocorticoid drugs in the treatment of depression
Autore:
Reus, VI; Wolkowitz, OM;
Indirizzi:
Univ Calif San Francisco, Dept Psychiat, Ctr Neurobiol & Behav, Sch Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 10, volume: 10, anno: 2001,
pagine: 1789 - 1796
SICI:
1354-3784(200110)10:10<1789:ADITTO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GENE-EXPRESSION; PITUITARY-ADRENAL SYSTEM; MAJOR-DEPRESSION; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; ANTIDEPRESSANT THERAPY; STEROID-BIOSYNTHESIS; KETOCONAZOLE; METYRAPONE; BRAIN;
Keywords:
allostasis; antidepressant; cortisol; glucocorticoid; ketoconazole; metyrapone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Reus, VI Univ Calif San Francisco, Dept Psychiat, Ctr Neurobiol & Behav, Sch Med, 401 Parnassus Ave,Box F-0984, San Francisco, CA 94143 USA Univ Calif San Francisco 401 Parnassus Ave,Box F-0984 San Francisco CA USA 94143
Citazione:
V.I. Reus e O.M. Wolkowitz, "Antiglucocorticoid drugs in the treatment of depression", EXPERT OP I, 10(10), 2001, pp. 1789-1796

Abstract

A confluence of evidence indicates that prolonged elevation in gluco-corticoid level may result in disturbances of mood and cognition. In Cushing's syndrome, hypersecretion of cortisol is associated with a high incidence of depression, impairment in memory and hippocampal atrophy. Pharmacological usage of glucocorticoids is similarly productive of mood change and memory deficit. In patients with endogenous depression, hypercortisolaemia is associated with cognitive dysfunction and possibly a decrease in hippocampal volume. In each of these conditions, reduction of glucocorticoid level, eitherthrough discontinuation of steroid treatment or through usage of agents that block glucocorticoid synthesis, ameliorates the adverse behavioural effects. Traditional antidepressant agents may, in addition, stabilise mood through actions on the hypothalamic-pituitary adrenocortical (HPA) system. Although clinical usage of the currently available antiglucocorticoid drugs islimited by significant adverse side effect profiles, development of drugs specifically targeting the glucocorticoid receptor may lead to innovative strategies in the treatment of mood disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:06:07