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Titolo:
Reflex-elicited increases in female rat parotid protein synthesis involving parasympathetic non-adrenergic, non-cholinergic mechanisms
Autore:
Ekstrom, J; Reinhold, AC;
Indirizzi:
Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, SE-40530 Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden SE-40530 , SE-40530 Gothenburg, Sweden
Titolo Testata:
EXPERIMENTAL PHYSIOLOGY
fascicolo: 5, volume: 86, anno: 2001,
pagine: 605 - 610
SICI:
0958-0670(200109)86:5<605:RIIFRP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; GENE-RELATED PEPTIDE; SUBSTANCE-P; SALIVARY-GLANDS; NERVE-STIMULATION; ACETYLTRANSFERASE ACTIVITY; ACINAR GRANULES; SECRETION; DEPLETION; ATROPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ekstrom, J Univ Gothenburg, Dept Pharmacol, Inst Physiol & Pharmacol, Box 431, SE-40530 Gothenburg, Sweden Univ Gothenburg Box 431 Gothenburg SwedenSE-40530 urg, Sweden
Citazione:
J. Ekstrom e A.C. Reinhold, "Reflex-elicited increases in female rat parotid protein synthesis involving parasympathetic non-adrenergic, non-cholinergic mechanisms", EXP PHYSIOL, 86(5), 2001, pp. 605-610

Abstract

Normal rats or rats parasympathetically denervated on one side by cutting the auriculo-temporal nerve were maintained on a liquid diet for I week. After fasting overnight, experimental rats were then offered hard, pelleted food over a Period of 2 h, while unfed animals served as controls. The reflex-induced increase in the [H-3]leucine incorporation into trichloroacetic acid-insoluble material of the parotid glands following intake of the food in the presence of the muscarinic blocker atropine and alpha- and beta -adrenoceptor antagonists was greater (104%) than in the absence of the blockers(75%) in normal rats. The picture was the same when the innervated glands of rats subjected to unilateral parasympathetic denervation were examined. In this case, the protein synthesis increased by 108% in the presence of the blockers and by 63% in their absence. Analysis of the parasympatheticallydenervated and contralateral innervated glands revealed no support for a cholinergic or adrenergic contribution to this response. The increase in protein synthesis in the innervated glands was 86% in the rats treated with atropine, whilst it was 76% in those treated with alpha- and beta -adrenoceptor antagonists. The protein synthesis in the denervated glands increased by57% in the absence of receptor blockade. Neither atropine (51%), nor a- and b-adrenoceptor antagonists (52%), nor a combination of the three blockers(55%) affected the response of the denervated glands. A large part of the response in the presence of the traditional autonomic receptor blockers wasthus dependent on the parasympathetic auriculo-temporal nerve. Under natural feeding conditions, the parasympathetic non-adrenergic, non-cholinergic (NANC) mechanisms are likely to contribute to the synthesis of secretory proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 18:08:10