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Titolo:
Hypothalamic pituitary adrenal axis and hypothalamic-neurohypophyseal responsiveness in water-deprived rats
Autore:
Grinevich, V; Ma, XM; Verbalis, J; Aguilera, G;
Indirizzi:
Georgetown Univ, Dept Med, Washington, DC USA Georgetown Univ Washington DC USA own Univ, Dept Med, Washington, DC USA NICHHD, Sect Endocrine Physiol, Dev Endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 docrinol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 171, anno: 2001,
pagine: 329 - 341
SICI:
0014-4886(200110)171:2<329:HPAAAH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; VASOPRESSIN GENE-EXPRESSION; MESSENGER-RNA; ADRENOCORTICOTROPIN SECRETION; ARGININE-VASOPRESSIN; MAGNOCELLULAR NEURONS; NEUROSECRETORY-SYSTEM; RECEPTOR ANTAGONIST; SUPRAOPTIC NUCLEI; STRESS;
Keywords:
hypothalamus; parvocellular neurons; magnocellular neurons; immune challenge; immobilization; osmotic stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Grinevich, V Univ Jena, Klinikum, Inst Anat 2, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 nat 2, D-07740 Jena, Germany
Citazione:
V. Grinevich et al., "Hypothalamic pituitary adrenal axis and hypothalamic-neurohypophyseal responsiveness in water-deprived rats", EXP NEUROL, 171(2), 2001, pp. 329-341

Abstract

The differential effects of osmotic stimulation on magnocellular and parvocellular hypothalamic neurons were studied by analysis of corticotropin-releasing hormone (CRH) and vasopressin (VP) expression in controls and 48-h water-deprived rats subjected to either restraint for 1 h or a single lipopolysaccharide injection (250 mug/100 g). Water deprivation reduced basal CRHmRNA levels but the increments following 4 h of restraint or 6 h lipopolysaccharide (LPS) injection were similar to those in controls. In contrast, water deprivation had no effect on basal VP heteronuclear RNA (hnRNA) and mRNA levels in parvocellular neurons, but responses to restraint or LPS injection were reduced. VP expression in magnocellular paraventricular and supraoptic nuclei, and plasma sodium and vasopressin were higher in water-deprived rats, changes which were unaffected by restraint. LPS injection reduced VP mRNA but not hnRNA levels in magnocellular neurons and increased plasma vasopressin levels only in water-deprived rats independently of changes in plasma sodium. This was accompanied by an increase in vasopressin mRNA content in the posterior pituitary. The data show that the blunted ACTH responses to acute stress during chronic osmotic stimulation are correlated with the inability of parvocellular neurons to increase VP rather than CRH expression. In addition, LPS-induced endotoxemia causes disturbances of the magnocellular vasopressinergic system with an unexpected potentiation of osmoticsimulated VP secretion. The lack of increase in VP transcription after LPSand changes in VP mRNA distribution suggest that endotoxemia affect the secretory process at the levels of the neurohypophyseal axon terminal. (C) 2001 Academic Press.

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Documento generato il 04/12/20 alle ore 02:56:52