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Titolo:
Histaminergic control of oxytocin release in the paraventricular nucleus during lactation in rats
Autore:
Bealer, SL; Crowley, WR;
Indirizzi:
Univ Tennessee, Dept Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Dept Physiol, Memphis, TN 38163 USA Univ Tennessee, Dept Pharmacol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 Dept Pharmacol, Memphis, TN 38163 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 171, anno: 2001,
pagine: 317 - 322
SICI:
0014-4886(200110)171:2<317:HCOORI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MILK-EJECTION REFLEX; SUPRAOPTIC NUCLEUS; VASOPRESSIN RELEASE; CONSCIOUS RAT; NEURONS; BRAIN; STIMULATION; NOREPINEPHRINE; MICRODIALYSIS;
Keywords:
suckling; nursing; intranuclear oxytocin; microdialysis; histamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Bealer, SL Univ Tennessee, Dept Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 iol, Memphis, TN 38163 USA
Citazione:
S.L. Bealer e W.R. Crowley, "Histaminergic control of oxytocin release in the paraventricular nucleus during lactation in rats", EXP NEUROL, 171(2), 2001, pp. 317-322

Abstract

The central neurotransmitters regulating both systemic and central releaseof oxytocin (OT) during lactation are not completely defined. Although central histaminergic systems have been implicated in systemic release of OT, the role of this neurotransmitter in suckling-induced intranuclear OT secretion has not been investigated. Therefore, microdialysis of the paraventricular nucleus (PVN) was used to determine if suckling stimulates histamine release within the PVN and if nursing-induced intranuclear OT release is reduced by local blockade of either H1 or H2 histamine receptors. Female Holtzman rats were implanted wit microdialysis probes adjacent to the PVN on lactation days 8-12. The next day, the pups and dam were separated for 4 h, reunited, and again separated. Histamine concentrations in dialysates were measured before, during, and following suckling. In separate animals, a similar separation/reunion paradigm was used, but the dialysate OT concentrationwas measured during PVN perfusion with vehicle or an H1 or H2 receptor antagonist. Suckling increased dialysate concentrations of both histamine and OT in the PVN. Furthermore, local pharmacological blockade of either H1 or H2 receptors prevented the increase in OT release in the PVN during suckling. These data demonstrate that activation of histamine receptors in the PVNis necessary for intranuclear release of OT induced by suckling and extendprevious findings demonstrating a similar relationship between central histamine and systemic release of OT. (C) 2001 Academic Press.

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Documento generato il 25/10/20 alle ore 06:58:35