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Titolo:
Temporary warm ischaemia, 5/6 nephrectomy and single uranyl nitrate administration - comparison of three models intended to cause renal fibrosis in rats
Autore:
Appenroth, D; Lupp, A; Kriegsmann, J; Sawall, A; Splinther, J; Sommer, M; Stein, G; Fleck, C;
Indirizzi:
Univ Jena, Inst Pharmakol & Toxikol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 harmakol & Toxikol, D-07740 Jena, Germany Univ Mainz, Inst Pathol, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 ainz, Inst Pathol, D-6500 Mainz, Germany Univ Jena, Dept Internal Med 4, Jena, Germany Univ Jena Jena GermanyUniv Jena, Dept Internal Med 4, Jena, Germany
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 4, volume: 53, anno: 2001,
pagine: 316 - 324
SICI:
0940-2993(200109)53:4<316:TWI5NA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBULOINTERSTITIAL FIBROSIS; ISCHEMIA/REPERFUSION INJURY; FAILURE; PATHOGENESIS; ISCHEMIA; KIDNEY; PREVENTION; COLLAGEN; BINDING; DAMAGE;
Keywords:
interstitial fibrosis; ischaemia; 5/6 nephrectomy; uranyl nitrate; OH-proline; creatinine clearance; proteinuria; morphology; time course; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Appenroth, D Univ Jena, Inst Pharmakol & Toxikol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 xikol, D-07740 Jena, Germany
Citazione:
D. Appenroth et al., "Temporary warm ischaemia, 5/6 nephrectomy and single uranyl nitrate administration - comparison of three models intended to cause renal fibrosis in rats", EXP TOX PAT, 53(4), 2001, pp. 316-324

Abstract

In patients the progression of pathologic renal processes after the treatment of primary disease is a problem of increasing importance and therapeutic strategies are insufficient till now. The aim of this paper was to searchfor rat models of interstitial fibrosis as a basis for testing therapeuticstrategies to prevent end-stage renal failure. Experiments were done on adult female Wistar rats (Han:Wist) to investigate long-term consequences of temporary warm ischaemia, 5/6 nephrectomy (5/6 NX) and sing e uranyl nitrate (UN) administration (0.3 or 0.5 mg/100 g bodywt, intraperitoneally). Observation time was 20 weeks after injury in eachgroup. Creatinine clearance, urinary protein excretion and hydroxy-proline(OH-proline) concentration in renal tissue were measured and light microscopic investigations were done to characterise both quality and time course of long-term renal damage in relation to matched control animals. Temporarywarm ischaemia and 5/6 NX did not cause any fibrotic changes during the 20weeks observation period. In conclusion, administration of one single dose of UN is a simple procedure to induce interstitial renal fibrosis as an experimental model to investigate therapeutic strategies for their prevention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:47:05