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Titolo:
Repetitive administration of tetrabenazine induces irreversible changes inlocomotion and morphology of the substantia nigra in rats
Autore:
Satou, T; Anderson, AJ; Itoh, T; Tamai, Y; Hayashi, Y; Hashimoto, S;
Indirizzi:
Kinki Univ, Sch Med, Dept Pathol 2, Osaka 5898511, Japan Kinki Univ Osaka Japan 5898511 Med, Dept Pathol 2, Osaka 5898511, Japan Univ Calif Irvine, Inst Brian Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ng & Dementia, Irvine, CA 92717 USA Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 5898511, Japan Kinki UnivOsaka Japan 5898511 Dept Internal Med 3, Osaka 5898511, Japan
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 4, volume: 53, anno: 2001,
pagine: 303 - 308
SICI:
0940-2993(200109)53:4<303:RAOTII>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE; BRAIN; 6-HYDROXYDOPAMINE; HYPOTHESIS; TOXICITY; BINDING; RELEASE; CELLS; DRUG;
Keywords:
tetrabenazine; Parkinson's disease; behavior; locomotion; substantia nigra pars compacta; mid brain; morphometry; monoamine; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Satou, T Kinki Univ, Sch Med, Dept Pathol 2, 377-2 Ohnohigashi Osakasayama, Osaka 5898511, Japan Kinki Univ 377-2 Ohnohigashi Osakasayama Osaka Japan 5898511 pan
Citazione:
T. Satou et al., "Repetitive administration of tetrabenazine induces irreversible changes inlocomotion and morphology of the substantia nigra in rats", EXP TOX PAT, 53(4), 2001, pp. 303-308

Abstract

We investigated the effects of a 7 day repetitive administration of tetrabenazine (TBZ), which depletes monoamines, on both locomotor behavior and histomorphometrial findings of substantia nigra in rats. These results were compared with the effects of a single dose of TBZ, which is a common paradigm in animal models of depression. A single dose of TBZ causes reversible decrease of voluntary movement and no histological changes. In contrast, as for repetitive administration, this experiment demonstrated irreversible andsignificant decrease in spontaneous locomotion, as well as histological changes in the neurons of the substantia nigra pars compacta. These results have led us to propose that prolonged TBZ administration could provide a novel and useful model for the behavioral characteristics and anatomical pathology of Parkinson's disease as one of the oxidative stress models induced by abnormal dopamine metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:41:26