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Titolo:
Comparison of pharmacokinetic MRI and [F-18] fluorodeoxyglucose PET in thediagnosis of breast cancer: initial experience
Autore:
Brix, G; Henze, M; Knopp, MV; Lucht, R; Doll, J; Junkermann, H; Hawighorst, H; Haberkorn, U;
Indirizzi:
DKFZ, German Canc Res Ctr, Res Program Radiol Diagnost & Therapy, D-69120 Heidelberg, Germany DKFZ Heidelberg Germany D-69120 t & Therapy, D-69120 Heidelberg, Germany Fed Off Radiat Protect, Inst Radiat Hyg, Dept Med Radiat Hyg, D-85764 Oberschleissheim, Germany Fed Off Radiat Protect Oberschleissheim Germany D-85764 issheim, Germany Univ Heidelberg, Dept Nucl Med, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Univ Heidelberg, Dept Gynaecol Radiol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany
Titolo Testata:
EUROPEAN RADIOLOGY
fascicolo: 10, volume: 11, anno: 2001,
pagine: 2058 - 2070
SICI:
0938-7994(2001)11:10<2058:COPMA[>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; ITERATIVE IMAGE-RECONSTRUCTION; CONTRAST-ENHANCED MRI; OF-THE-ART; GD-DTPA; PERFORMANCE EVALUATION; DATA-ACQUISITION; FDG UPTAKE; OVERRELAXATION; PARAMETERS;
Keywords:
breast cancer; dynamic MRI-2-[F-18]fluoro-2-deoxy-D-glucose; PET; functional imaging; image correlation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Brix, G DKFZ, German Canc Res Ctr, Res Program Radiol Diagnost & Therapy, D-69120 Heidelberg, Germany DKFZ Heidelberg Germany D-69120 apy, D-69120 Heidelberg, Germany
Citazione:
G. Brix et al., "Comparison of pharmacokinetic MRI and [F-18] fluorodeoxyglucose PET in thediagnosis of breast cancer: initial experience", EUR RADIOL, 11(10), 2001, pp. 2058-2070

Abstract

It was the aim of this methodology-oriented clinical pilot study to compare the potential of dynamic MRI and 2-[F-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) for the detection and characterization ofbreast cancer. Fourteen women with suspicious breast lesions were examined. The MRI data were acquired with a turbo fast low-angle shot sequence and analyzed using a pharmacokinetic model. Emission data were detected in the sensitive 3D modus, iteratively reconstructed, and superimposed onto corresponding transmission images. In the 14 patients, 13 breast masses with a suspicious contrast enhancement and FDG uptake were detected. For these lesions, no statistically significant correlation between evaluated MR and PET parameters was found. Of the 9 histologically confirmed carcinomas, 8 were correctly characterized with MRI and PET. Two inflammatory lesions were concordantly classified as cancer. Moreover, dynamic MRI yielded another false-positive finding. In 6 patients, PET detected occult lymph node and/or distant metastases. Although both functional imaging techniques provide independent tissue information, the results concerning the diagnosis of primary breast lesions were almost identical. An advantage of PET, however, is its ability to localize lymph node involvement and distant metastases as an integral part of the examination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:39:14