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Titolo:
Stereolithographic models simulating trabecular bones and their characterization by thin-slice- and micro-CT
Autore:
Engelke, K; Suss, C; Kalender, WA;
Indirizzi:
Univ Erlangen Nurnberg, Inst Med Phys, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
EUROPEAN RADIOLOGY
fascicolo: 10, volume: 11, anno: 2001,
pagine: 2026 - 2040
SICI:
0938-7994(2001)11:10<2026:SMSTBA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTED-TOMOGRAPHY; DISTAL RADIUS; TEXTURE ANALYSIS; CANCELLOUS BONE; IMAGE-ANALYSIS; ARCHITECTURE; CALCANEUS; MEDICINE; BIOPSIES; INVIVO;
Keywords:
bone; structure; phantoms; stereolithography; thin-slice CT; micro-CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Engelke, K Univ Erlangen Nurnberg, Inst Med Phys, Krankenhausstr 12, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Krankenhausstr 12 Erlangen Germany D-91054
Citazione:
K. Engelke et al., "Stereolithographic models simulating trabecular bones and their characterization by thin-slice- and micro-CT", EUR RADIOL, 11(10), 2001, pp. 2026-2040

Abstract

The analysis of bone structure in vivo is an important goal in osteoporosis, because the determination of bone mineral density alone is insufficient to predict whether an individual patient will eventually suffer an osteoporotic fracture or not. An additional structural analysis may significantly improve the statistical assessment of fracture risk. In this study we present a method to generate realistic although enlarged 3D phantoms of trabecular bone. These phantoms are useful in characterizing the potential of in vivo imaging, procedures for the analysis of bone structure and to verify textural or structural analysis methods applied to these images. Our phantoms are based on a real trabecular bone specimen that was converted to a plasticmodel using the technique of stereolithography. The trabecular network is modeled by hydroxyapatite. Limitations of the stereolithographic process prevent the generation of exact 1:1 replicas of the real bone. A histomorphometric analysis Of LCT scans of the phantoms showed that an excellent replication of the bone structure could be achieved in phantoms enlarged by a factor of 2.5 with "trabecular" hydroxyapatite concentrations up to 400 mg/cm(3). In order to demonstrate the usefulness of our phantoms, we investigatedone of them with various thin-slice CT protocols using clinical single-andmulti-slice spiral CT scanners. The enlargement of the phantoms limits their use on high spatial resolution CT scanners (resolution > 20 lp/cm). The limited hydroxyapatite concentration requires enhanced exposure rates for the phantoms scans to offset the larger impact of noise due to the lower contrast in the phantoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:19:59