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Titolo:
Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice
Autore:
Kaur, G; Kulkarni, SK;
Indirizzi:
Punjabi Univ, Inst Pharm Sci, Div Pharmacol, Chandigarh 160014, India Punjabi Univ Chandigarh India 160014 Pharmacol, Chandigarh 160014, India
Titolo Testata:
EUROPEAN JOURNAL OF NUTRITION
fascicolo: 3, volume: 40, anno: 2001,
pagine: 127 - 133
SICI:
1436-6207(200106)40:3<127:IOPSII>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID OXIDATION; RATS; FLUOXETINE; FENFLURAMINE; 8-OH-DPAT; ANOREXIA;
Keywords:
serotonin; food intake; OB-200G; fluoxetine; female mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kulkarni, SK Punjabi Univ, Inst Pharm Sci, Div Pharmacol, Chandigarh 160014, India Punjabi Univ Chandigarh India 160014 andigarh 160014, India
Citazione:
G. Kaur e S.K. Kulkarni, "Investigations on possible serotonergic involvement in effects of OB-200G (polyherbal preparation) on food intake in female mice", EUR J NUTR, 40(3), 2001, pp. 127-133

Abstract

Background OB-200G is a polyherbal preparation containing aqueous extractsof Garcinia cambogia, Gymnema sylvestre, Zingiber officinale, Piper longumand resin from Commiphora mukul, all possessing thermogenic properties. Our previous studies reveal OB-200G to exert antiobesity effects in dietary animal models of obesity. Aim of the study The present study investigated the possible involvement of serotonergic system in the effect of OB-200G on food intake. We examined the effects of systemic pretreatment with 5-HT depletor, p-chlorophenylalanine (PCPA, 300 mg/kg, i.p. for 6 days), 5-HT1A agonist, (8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT, 0.1 mg/kg, i.p.),nonselective 5-HT antagonist, cyproheptadine (1 mg/kg, i.p.), 5-HT2 receptor antagonist, seganserin (1 and 2 mg/kg, i.p.) and 2-deoxy-D-glucose (2-DG, glucose antimetabolite, 500 mg/kg, i.p.) on satiety induced by OB -200G (500 mg/kg, p.o.) in non-deprived female mice. The results were compared with fluoxetine (10 mg/kg, i.p.), a selective serotonin reuptake inhibitor. Methods Fifteen minutes after the last drug administration, groups of mice were presented with sweetened chow and the amount of food consumed was recorded at 0.5,1,2, 3 and 4h time intervals. Results The hyperphagic effect of PCPA, 8-OH-DPAT, cyproheptadine and 2-DG was significantly (p < 0.05) antagonized by both OB-200G and fluoxetine. However, the anorectic effect of fluoxetine was not reversed by centrally acting 5-HT2 antagonist, seganserin but the latter markedly attenuated the satiety action of OB-200G. Conclusion The present observations suggest the role of serotonin in mediation of satiety by OB-200G and hence its antiobesity effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:48:12