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Titolo:
Beneficial role for folate in the prevention of colorectal and breast cancer
Autore:
Prinz-Langenohl, R; Fohr, I; Pietrzik, K;
Indirizzi:
Univ Bonn, Dept Pathophysiol Human Nutr, Inst Nutr Sci, D-53115 Bonn, Germany Univ Bonn Bonn Germany D-53115 utr, Inst Nutr Sci, D-53115 Bonn, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUTRITION
fascicolo: 3, volume: 40, anno: 2001,
pagine: 98 - 105
SICI:
1436-6207(200106)40:3<98:BRFFIT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA METHYLATION; COLON-CANCER; METHYLENETETRAHYDROFOLATE REDUCTASE; FOLIC-ACID; URACIL MISINCORPORATION; ULCERATIVE-COLITIS; RISK; HYPOMETHYLATION; DEFICIENCY; METHIONINE;
Keywords:
folate; folic acid; colorectal cancer; breast cancer; risk reduction; prevention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Prinz-Langenohl, R Univ Bonn, Dept Pathophysiol Human Nutr, Inst Nutr Sci,Endenicher Allee 11-13, D-53115 Bonn, Germany Univ Bonn Endenicher Allee 11-13 Bonn Germany D-53115
Citazione:
R. Prinz-Langenohl et al., "Beneficial role for folate in the prevention of colorectal and breast cancer", EUR J NUTR, 40(3), 2001, pp. 98-105

Abstract

Folate is involved in the synthesis of nucleotides and amino acid metabolism such as methylation of homocysteine to methionine. Methionine is activated by adenosine triphosphate (ATP) to produce S-adenosylme-thionine (SAM), the primary intracellular methyl donor. Thus, folate is essential for the synthesis, methylation, and repair of DNA. With regard to its biochemical function it has been hypothesized that a diminished folate status may contribute to carcinogenesis by alteration of gene expression and increased DNA damage. Animal and human studies support this hypothesis, particularly with respect to colorectal cancer. Epidemiological evidence for the association between folate status and cancer was first observed among ulcerative colitispatients. Several case-control studies demonstrated reduction in colorectal cancer risk with better folate status. Two large, prospective cohort studies support the concept that high folate intake is protective against coloncancer. In contrast to colorectal cancer, the potential association of folate status and risk has been less investigated in breast cancer. Recently, convincing epidemiological data establishing a positive effect of folate status on breast cancer risk were published. This review summarizes the epidemiological evidence for the association between folate status and colorectal and breast cancer risk. In addition, a short overview is given on the discussed mechanism(s) by which folate might be involved in carcinogenesis.

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Documento generato il 05/07/20 alle ore 12:21:18