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Titolo:
Involvement of intrinsic cholinergic and GABAergic innervation in the effect of NMDA on striatal dopamine efflux and metabolism as assessed by microdialysis studies in freely moving rats
Autore:
Whitehead, KJ; Rose, S; Jenner, P;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomass Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL r, London SE1 1UL, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 851 - 860
SICI:
0953-816X(200109)14:5<851:IOICAG>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; IN-VIVO MICRODIALYSIS; MEDIAL FOREBRAIN-BUNDLE; EXCITATORY AMINO-ACIDS; CAT CAUDATE-NUCLEUS; TYROSINE-HYDROXYLASE; NERVE-TERMINALS; EXTRACELLULAR DOPAMINE; EVOKED RELEASE; ACETYLCHOLINE-RELEASE;
Keywords:
(+)-bicuculline; acetylcholine; atropine; GABA; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Whitehead, KJ Univ Birmingham, Sch Med, Dept Pharmacol, Div Neurosci, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT gland
Citazione:
K.J. Whitehead et al., "Involvement of intrinsic cholinergic and GABAergic innervation in the effect of NMDA on striatal dopamine efflux and metabolism as assessed by microdialysis studies in freely moving rats", EUR J NEURO, 14(5), 2001, pp. 851-860

Abstract

Microdialysis perfusion was used to study the participation of striatal cholinergic and gamma -aminobutyric acid-ergic (GABAergic) neurotransmission in basal and N-methyl-D-aspartate (NMDA) receptor-modulated dopamine release and metabolism in the striatum of the freely moving rat. Reverse dialysisof atropine (1-50 muM) induced a concentration-related increase in dopamine efflux and decrease in 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) efflux. (+)-Bicuculline (10-100 muM) similarly increased dopamine efflux, but was without consistent effect on metabolite efflux. Reverse dialysis of NMDA (1 mM) evoked an approximately twofold increase in dopamine efflux and decreased DOPAC and HVA efflux to 30-40% of basal levels. The effect of NMDA on dopamine efflux was completely abolished by coadministration of tetrodotoxin (TTX; 1 mum) or atropine (10 mum), and markedly potentiated (approximately fourfold) by coadministration of (+)-bicuculline (50 mum). The NMDA-induced decrease in dopamine metabolite efflux was inhibited by coadministration of TTX or (+)-bicuculline, but was unaffected by atropine. Our data suggest that dopamine release in the striatum is subject to both cholinergic and GABAergic tonic inhibitory mechanisms mediated through muscarinic and GABA(A) receptors, respectively. Furthermore, NMDA-stimulated dopamine release also involves obligatory cholinergic facilitation andan inhibitory GABAergic component mediated through these respective receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:45:30