Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Optical imaging of spreading depolarization waves triggered by spinal nerve stimulation in the chick embryo: possible mechanisms for large-scale coactivation of the central nervous system
Autore:
Mochida, H; Sato, K; Arai, Y; Sasaki, S; Kamino, K; Momose-Sato, Y;
Indirizzi:
Tokyo Med & Dent Univ, Grad Sch, Dept Physiol, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Fac Med, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan JAIC Coll Med Care & Welf Technol, Koriyama, Fukushima 9638834, Japan JAICColl Med Care & Welf Technol Koriyama Fukushima Japan 9638834 Japan
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 809 - 820
SICI:
0953-816X(200109)14:5<809:OIOSDW>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
VOLTAGE-SENSITIVE DYES; BRAIN-STEM; ELECTRICAL-ACTIVITY; NEURAL ACTIVITY; FUNCTIONAL-ORGANIZATION; NETWORK ACTIVITY; POTENTIOMETRIC PROBES; VAGAL-STIMULATION; NEURONAL-ACTIVITY; CORD;
Keywords:
chick embryo; depolarization wave; development; optical recording; spinal cord; voltage-sensitive dye;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Momose-Sato, Y Tokyo Med & Dent Univ, Grad Sch, Dept Physiol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 n
Citazione:
H. Mochida et al., "Optical imaging of spreading depolarization waves triggered by spinal nerve stimulation in the chick embryo: possible mechanisms for large-scale coactivation of the central nervous system", EUR J NEURO, 14(5), 2001, pp. 809-820

Abstract

Using a multiple-site optical recording technique with a voltage-sensitivedye, we found that widely spreading depolarization waves were evoked by dorsal root stimulation in embryonic chick spinal cords. Spatiotemporal maps of the depolarization waves showed that the signals were mainly distributedin the ventral half of the slice, with the highest activity in the ventrolateral area. The propagation velocity of the waves was estimated to be in the order of mm/s. Depolarization waves were evoked in the ventral root-cut preparation, but not in the dorsal root-cut preparation, suggesting that the wave was triggered by synaptic inputs from the primary afferents, and that activation of the motoneurons was not essential for wave generation. In intact spinal cord-brain preparations, the depolarization wave propagated rostrally and caudally for a distance of several spinal segments in normal Ringer's solution. In a Mg2+-free solution, the amplitude and extent of the signals were markedly enhanced, and the depolarization wave triggered in thecervical spinal cord propagated to the brainstem and the cerebellum. The depolarization wave demonstrated here had many similarities with the vagus nerve-evoked depolarization wave reported previously. The results suggest that functional cell-to-cell communication systems mediated by the depolarization wave are widely generated in the embryonic central nervous system, andcould play a role in large-scale coactivation of the neurons in the spinalcord and brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:57:51