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Titolo:
Choroid plexus and ageing in rats: a morphometric and ultrastructural study
Autore:
Serot, JM; Foliguet, B; Bene, MC; Faure, GC;
Indirizzi:
UHP Nancy 1, Fac Med, Immunol Lab, Nancy, France UHP Nancy 1 Nancy France P Nancy 1, Fac Med, Immunol Lab, Nancy, France UHP Nancy 1, Fac Med, Lab Microscopie Elect, Nancy, France UHP Nancy 1 Nancy France Fac Med, Lab Microscopie Elect, Nancy, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 794 - 798
SICI:
0953-816X(200109)14:5<794:CPAAIR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONSET ALZHEIMERS-DISEASE; CENTRAL-NERVOUS-SYSTEM; CEREBROSPINAL-FLUID; BASEMENT-MEMBRANE; TRANSTHYRETIN; PATHOLOGY; TISSUE; KIDNEY;
Keywords:
ageing; choroid plexus; morphometry; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Serot, JM Immunol Lab, Bp 184, F-54500 Vandoeuvre Les Nancy, France Immunol Lab Bp 184 Vandoeuvre Les Nancy France F-54500 , France
Citazione:
J.M. Serot et al., "Choroid plexus and ageing in rats: a morphometric and ultrastructural study", EUR J NEURO, 14(5), 2001, pp. 794-798

Abstract

Choroid plexuses (CP) are intraventricular structures involved in the production of cerebrospinal fluid (CSF) and in the synthesis and transport of numerous CSF components. Age-related modifications of the CP structure are still ill defined. We performed an ultrastructural and morphometric study ofageing CP in nine Sprague-Dawley rats 6, 18 and 30 months of age. Epithelial cells of CP villi were cubic in shape at 6 months, more dome-like at 18 months, and significantly flattened at 30 months of age. Epithelial basement membranes were thin and regular at 6 months, significantly thicker at 18 months and thicker and irregular at 30 months. Intravillous stroma increased nonhomogeneously with age. The ageing of CP in rats is characterized morphologically by epithelial atrophy, irregular fibrosis of the stroma and a thickening of epithelial basement membranes. These modifications suggest an alteration of secretory and filtrating functions in ageing CP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:42:41