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Titolo:
Glutamate receptor stimulation induces a persistent rhythmicity of the GABAergic inputs to rat midbrain dopaminergic neurons
Autore:
Berretta, N; Paolucci, E; Bernardi, G; Mercuri, NB;
Indirizzi:
Fdn Santa Lucia IRCCS, I-00179 Rome, Italy Fdn Santa Lucia IRCCS Rome Italy I-00179 ucia IRCCS, I-00179 Rome, Italy Univ Roma Tor Vergata, Neurol Clin, I-00173 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00173 eurol Clin, I-00173 Rome, Italy
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 5, volume: 14, anno: 2001,
pagine: 777 - 784
SICI:
0953-816X(200109)14:5<777:GRSIAP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; INHIBITORY INTERNEURONS; SUBTHALAMIC NUCLEUS; TRANSMISSION; OSCILLATIONS; HIPPOCAMPUS; GENERATION; NETWORKS; SYSTEM; SYNCHRONIZATION;
Keywords:
gap junctions; mGluR; neuronal networks; NMDA; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Berretta, N Fdn Santa Lucia IRCCS, Via Ardeatina 306, I-00179 Rome, Italy Fdn Santa Lucia IRCCS Via Ardeatina 306 Rome Italy I-00179 ly
Citazione:
N. Berretta et al., "Glutamate receptor stimulation induces a persistent rhythmicity of the GABAergic inputs to rat midbrain dopaminergic neurons", EUR J NEURO, 14(5), 2001, pp. 777-784

Abstract

The substantia nigra pars compacta and the ventral tegmental area are partof a complex network in the basal ganglia involved in behaviours as diverse as motor planning, generation of pleasure and drug addiction. Here we report that in the dopaminergic neurons of the rat ventral midbrain a brief coactivation of group I metabotropic and NMDA glutamate receptors may transform a temporally dispersed synaptic GABAergic input into a rhythmic pattern (range 4.5-22.5 Hz), probably through a mechanism involving electrotonic couplings. The plastic and long-lasting modification in the temporal code of the inhibitory synaptic activity induced by glutamate may be a key element in determining the function of midbrain dopaminergic neurons in both normaland pathological behaviour.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:51:52