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Titolo:
Topical application of vitamin A reverses metaplasia of rat vaginal epithelium - A rapid and efficient approach to improve mucosal barrier function
Autore:
Biesalski, HK; Sobeck, U; Weiser, H;
Indirizzi:
Univ Hohenheim, Dept Biol Chem & Nutr, D-70593 Stuttgart, Germany Univ Hohenheim Stuttgart Germany D-70593 utr, D-70593 Stuttgart, Germany
Titolo Testata:
EUROPEAN JOURNAL OF MEDICAL RESEARCH
fascicolo: 9, volume: 6, anno: 2001,
pagine: 391 - 398
SICI:
0949-2321(20010928)6:9<391:TAOVAR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
A-DEFICIENCY; RESPIRATORY-TRACT; TRACHEAL EPITHELIUM; LANGERHANS CELLS; IMMUNODEFICIENCY; CHILDREN; ASSOCIATION; RETINOL; DISEASE; IMMUNOSUPPRESSION;
Keywords:
vitamin A; retinyl palmitate; squamous epithelium; aronal (R) forte; oral health; barrier function; malnutrition; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Biesalski, HK Univ Hohenheim, Dept Biol Chem & Nutr, Fruwirthstr 12, D-70593 Stuttgart, Germany Univ Hohenheim Fruwirthstr 12 Stuttgart Germany D-70593 any
Citazione:
H.K. Biesalski et al., "Topical application of vitamin A reverses metaplasia of rat vaginal epithelium - A rapid and efficient approach to improve mucosal barrier function", EUR J MED R, 6(9), 2001, pp. 391-398

Abstract

Retinyl palmitate and its metabolites retinol and retinolc acid control growth and epithelial differentiation. Systemic or local vitamin A deficiencyinduced by malnutrition, continuous chemical irritation or locally inducedby inflammation causes squamous metaplastic changes in the epithelium of mucous membranes. We demonstrate that in an animal model topically applied retinyl palmitate can be taken up by the mucosal cells independently from the systemic supply. Under in vivo conditions metabolic changes in vaginal epithelium of rats were shown to be reversed by treatment with topical retinyl palmitate. After only two days treatment squamous metaplastic vaginal epithelium in rats shows a reversal of the epithelium into a normal phenotype which continues after cessation of the treatment for 7 to 11 days. Higher concentrations and longer retention times lead to a statistically significant (p = 0.025) increase in the protection time. These data demonstrate that squamous changes induced by vitamin A deficiency can be totally reversed with topicallyapplied retinyl palmitate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:08:44