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Titolo:
The fibrinolytic system in chronic renal failure
Autore:
Lottermoser, K; Petras, S; Poge, U; Fimmers, R; Hertfelder, HJ; Schiermeyer, B; Vetter, H; Dusing, R;
Indirizzi:
Univ Bonn, Med Poliklin, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 Bonn, Med Poliklin, D-53111 Bonn, Germany Univ Bonn, Zentrum Innere Med, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 Zentrum Innere Med, D-53111 Bonn, Germany Univ Bonn, Inst Expt Hamatol & Transfus Med, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 tol & Transfus Med, D-53111 Bonn, Germany Univ Bonn, Inst Med Stat, Dokumentat & Datenverarbeitung Klin, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 nverarbeitung Klin, D-53111 Bonn, Germany
Titolo Testata:
EUROPEAN JOURNAL OF MEDICAL RESEARCH
fascicolo: 9, volume: 6, anno: 2001,
pagine: 372 - 376
SICI:
0949-2321(20010928)6:9<372:TFSICR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; RISK FACTOR; MYOCARDIAL-INFARCTION; PLASMA HOMOCYSTEINE; FOLIC-ACID; DISEASE; HYPERHOMOCYSTEINEMIA; ERYTHROPOIETIN; INSUFFICIENCY; THROMBOSIS;
Keywords:
chronic renal failure; homocysteine; fibrinolysis; plasminogen activator inhibitor-1; tissue-plasminogen activator;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Dusing, R Univ Bonn, Med Poliklin, Wilhelmstr 35-37, D-53111 Bonn, GermanyUniv Bonn Wilhelmstr 35-37 Bonn Germany D-53111 1 Bonn, Germany
Citazione:
K. Lottermoser et al., "The fibrinolytic system in chronic renal failure", EUR J MED R, 6(9), 2001, pp. 372-376

Abstract

Background: Patients with chronic renal failure (CRF) face a high risk of cardiovascular morbidity and mortality. Impaired fibrinolysis has recently been acknowledged to function as a risk factor for cardiovascular ischemic complications. Whether changes in fibrinolytic function contribute to the increased cardiovascular risk in CRF, however, remains unclear. Methods: In the present study, tissue-plasminogen activator (t-PA) and itsmain antagonist plasminogen activator inhibitor-1 (PAI-1) were determined in 12 subjects with normal renal function (group A) [serum creatinine (Cr) < 1.3 mg/dl], 24 patients with impaired renal function (Cr 1.3-6.5 mg/dl) (group B) and 22 patients with endstage renal disease (ESRD) on hemodialysis(Cr > 6.5 mg/dl) (group c). Results: Plasma concentrations of PAI-1 and t-PA antigen as well as the PAI-1:t-PA molar ratio were unchanged in group B as compared to group A. However, in ESRD patients (group C), t-PA concentrations markedly decreased [13.7 +/- 2.9 ng/ml vs. 32.8 +/- 4.7 ng/ml (group B, p < 0.01) and 35.4 +/- 8.4 ng/ml (group A, p < 0.01)] while PAI-1 antigen concentrations remained inthe control range. Thus, the PAI-1:t-PA molar ratio significantly increased in group C patients [12.4 +/- 4. 0 vs. 6.0 +/- 2.5 (group B; p<0.01) and 4.5 +/- 1.7 (group A;p<0.01]. Conclusions: From our data it may be suggested that fibrinolysis is markedly disturbed in ESRD due to a decreased availability of t-PA. Thus, it may be speculated that the development of atherothrombotic events in hemodialysis patients is, at least in part, due to an impaired fibrinolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:21:41