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Titolo:
Outcome after unilateral lung volume reduction surgery in patients with severe emphysema
Autore:
Geiser, T; Schwizer, B; Krueger, T; Gugger, M; Hof, VI; Dusmet, M; Fitting, JW; Ris, HB;
Indirizzi:
Univ Hosp Bern, Div Pulm Med, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 m Med, CH-3010 Bern, Switzerland Univ Lausanne Hosp, Dept Surg, Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland ept Surg, Lausanne, Switzerland Univ Lausanne Hosp, Div Pulm Med, Lausanne, Switzerland Univ Lausanne Hosp Lausanne Switzerland Pulm Med, Lausanne, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 674 - 678
SICI:
1010-7940(200110)20:4<674:OAULVR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM; LONG; APPROPRIATE; SURVIVAL;
Keywords:
pulmonary emphysema; lung volume reduction surgery; unilateral; outcome; prospective study; human; video-assisted surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Geiser, T Univ Hosp Bern, Div Pulm Med, CH-3010 Bern, Switzerland Univ Hosp Bern Bern Switzerland CH-3010 3010 Bern, Switzerland
Citazione:
T. Geiser et al., "Outcome after unilateral lung volume reduction surgery in patients with severe emphysema", EUR J CAR-T, 20(4), 2001, pp. 674-678

Abstract

Objective: Bilateral lung volume reduction surgery (LVRS) has emerged as apalliative treatment option in patients with severe pulmonary emphysema. However, it is not known if a sustained functional improvement can be obtained using an unilateral approach. Methods: We hypothesized that a palliativeeffect can also be obtained by unilateral LVRS and prospectively assessed lung function, walking distance, and dyspnea before and 3, 6, 12, 18. 24 and 36 months after unilateral LVRS, Results: Twenty-eight patients were operated by the use of video-assisted thoracoscopic surgery (VATS) with a mean follow-up of 16.5 months (range 3-36 months). Forced expiratory volume in 1s (FEV1) was significantly improved up to 3 months (1007 +/- 432 compared to 1184 +/- 499 ml, P < 0.001), residual volume up to 24 months (4154 +/- 1126 compared to 3390 +/- 914 ml. P < 0.01) dyspnea up to 12 months (modified Borg dyspnea scale 6.6 +/- 1.8 compared to 3.9 +/- 1.8. P = 0.01) and walking distance up to 24 months (343 +/- 107 compared to 467 +/- 77 m. P < 0.05) after unilateral LVRS compared to preoperative values. Overall, 25 of 28 patients reported a subjective benefit after unilateral LVRS. There was no 30-day mortality. Only two patients required surgery on the contralateralside after 4.5 and 6 months. respectively, both suffering from alpha -1-antitrypsin deficiency. Conclusions: Unilateral LVRS by the use of VATS results in a sustained beneficial effect. improving walking distance and dyspneafor up to 24 months in patients with severe emphysema. The preservation ofthe contralateral side for future intervention if required renders unilateral LVRS an attractive concept in this difficult palliative situation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:40:27