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Titolo:
Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study
Autore:
Franz, M; Dlabal, H; Kunz, S; Ulferts, J; Gruppe, H; Gallhofer, B;
Indirizzi:
Univ Giessen, Sch Med, Ctr Psychiat, Social Psychiat, D-35385 Giessen, Germany Univ Giessen Giessen Germany D-35385 Psychiat, D-35385 Giessen, Germany Hosp Psychiat, Ctr Social Psychiat Marburg Sud, D-35039 Marburg, Germany Hosp Psychiat Marburg Germany D-35039 burg Sud, D-35039 Marburg, Germany
Titolo Testata:
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
fascicolo: 4, volume: 251, anno: 2001,
pagine: 185 - 192
SICI:
0940-1334(200108)251:4<185:TOAWTA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANAGEMENT; CHLORMETHIAZOLE; PHARMACOLOGY; AGITATION; SYMPTOMS; THERAPY; TRIAL;
Keywords:
tiapride; carbamazepine; clomethiazol; alcohol with drawal syndrome; delirium tremens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Franz, M Univ Giessen, Sch Med, Ctr Psychiat, Social Psychiat, Steg 24, D-35385 Giessen, Germany Univ Giessen Steg 24 Giessen Germany D-35385 85 Giessen, Germany
Citazione:
M. Franz et al., "Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study", EUR ARCH PS, 251(4), 2001, pp. 185-192

Abstract

In Germany, clomethiazole (CLO) and benzodiazepines are predominantly usedas therapeutic agents in the treatment of the alcohol withdrawal syndrome (AWS). These agents have disadvantages such as sedation, risk of respiratory insufficiency, and cardiovascular complications as well as addictive potential. Alternatively, it could be demonstrated that both tiapride (TIA) andcarbamazepine (CBZ) are efficient in the treatment of AWS with less toxicity. However, they seem to be less effective in AWS than CLO as single agents. But no systematic comparison of the combination of TIA and CBZ against an established therapeutic standard can be found in the literature. Therefore, we compared the combination of TIA and CBZ with CLO in two open exploratory studies with matched samples. Outcome parameters were heart rate, bloodpressure, complications, withdrawal symptoms (CIWA-Ar scale), and general clinical state (CGI scale). A retrospective evaluation of medical records (30 TIA + CBZ, 30 CLO) was followed by an open prospective study (40 TIA + CBZ, 40 CLO). Both studies revealed similar efficacy in terms of psychopathologic and vegetative symptoms. Vegetative recovery seems to be faster with TIA + CBZ. Results of this exploratory study have to be confirmed by a controlled double-blind study with severity of AWS as an experimental factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:01:27