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Titolo:
Clinical evaluation of defibrillation efficacy with a new single-capacitorbiphasic waveform in patients undergoing implantation of an implantable cardioverter defibrillator
Autore:
Brugada, J; Herse, B; Sandsted, B; Michel, U; Schubert, BD; Hahn, SJ;
Indirizzi:
Univ Barcelona, Hosp Clin, Cardiovasc Inst, Arrhythmia Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ia Unit, E-08036 Barcelona, Spain Univ Clin, Gottingen, Germany Univ Clin Gottingen GermanyUniv Clin, Gottingen, Germany Univ Clin, Gothenburg, Sweden Univ Clin Gothenburg SwedenUniv Clin, Gothenburg, Sweden Guidant Res, Brussels, Belgium Guidant Res Brussels BelgiumGuidant Res, Brussels, Belgium Guidant Tachyarrhythmia Res, St Paul, MN USA Guidant Tachyarrhythmia Res St Paul MN USA rhythmia Res, St Paul, MN USA
Titolo Testata:
EUROPACE
fascicolo: 4, volume: 3, anno: 2001,
pagine: 278 - 284
SICI:
1099-5129(200110)3:4<278:CEODEW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERNAL DEFIBRILLATION; SMALLER CAPACITORS; HUMANS; FORMS; 90-MU-F; THERAPY; SYSTEM; SIZE;
Keywords:
human; defibrillation; pulse-waveform; capacitor; pulse-waveform tilt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Brugada, J Univ Barcelona, Hosp Clin, Cardiovasc Inst, Arrhythmia Unit, C Villarroel 170, E-08036 Barcelona, Spain Univ Barcelona C Villarroel 170 Barcelona Spain E-08036 Spain
Citazione:
J. Brugada et al., "Clinical evaluation of defibrillation efficacy with a new single-capacitorbiphasic waveform in patients undergoing implantation of an implantable cardioverter defibrillator", EUROPACE, 3(4), 2001, pp. 278-284

Abstract

Aims Improvements in the size and shape of implantable cardioverter defibrillators (ICDs) might be obtained by using one capacitor instead of the series connection of two capacitors traditionally used in ICDs. The aim of this study was to determine whether a biphasic waveform delivered from a single 336 muF capacitor had the same defibrillation efficacy as a standard biphasic waveform. Methods and Results Randomized. paired defibrillation threshold testing was acutely performed in 54 patients undergoing ICD implantation. A standard 140 muF 80% tilt biphasic waveform (two 280 muF capacitors connected in series) was compared with an experimental biphasic waveform delivered from a single 336 muF capacitor at either 60% tilt (33 patients) or 80% tilt (21 patients). All waveforms had a 60/40 phase1/phase2 duration ratio. Compared with the standard waveform, the 60% tilt experimental waveform had a lower delivered energy (6.7 +/- 2.8 vs 7.9 +/- 3.3 joules, P < 0.02), lower peak voltage (218 +/- 43 vs 333 +/- 68 V, P < 0.01), and a slightly longer pulse duration (13.4 +/- 1.4 vs 10.7 +/- 1.1 ms, P < 0-01). Conversely, the 80% tilt experimental waveform had a higher delivered energy (9.1 +/- 3.5 vs 6.3+/- 2.4 joules, P < 0.01), a lower peak voltage (234 +/- 44 vs 302 +/- 51 V, P < 0.01) and a much longer pulse duration (25.7 +/- 2.5 vs 11.3 +/- 1 ms, P < 0.01). Conclusion Waveforms delivered from a large capacitance are feasible but require a lower tilt. This technique may allow smaller. thinner ICDs withoutjeopardizing defibrillation success. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:36:37