Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hormonal regulation of oxytocin-induced prostaglandin F-2 alpha secretion by the bovine and ovine uterus in vivo
Autore:
Mann, GE; Payne, JH; Lamming, GE;
Indirizzi:
Univ Nottingham, Sch Biosci, Div Anim Physiol, Loughborough LE12 5RD, Leics, England Univ Nottingham Loughborough Leics England LE12 5RD 2 5RD, Leics, England
Titolo Testata:
DOMESTIC ANIMAL ENDOCRINOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 127 - 141
SICI:
0739-7240(200108)21:2<127:HROOPF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIECTOMIZED EWES; EARLY-PREGNANCY; PLASMA-CONCENTRATIONS; UTERINE SECRETION; GENE-EXPRESSION; ESTROUS-CYCLE; F-ALPHA; PROGESTERONE; ESTRADIOL; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, GE Univ Nottingham, Sch Biosci, Div Anim Physiol, Loughborough LE12 5RD, Leics, England Univ Nottingham Loughborough Leics England LE12 5RD ics, England
Citazione:
G.E. Mann et al., "Hormonal regulation of oxytocin-induced prostaglandin F-2 alpha secretion by the bovine and ovine uterus in vivo", DOM ANIM EN, 21(2), 2001, pp. 127-141

Abstract

In long-term ovariectomized ewes and cows, endometrial oxytocin receptors rest at relatively high levels but oxytocin is unable to induce prostaglandin F-2 alpha release. A series of studies were carried out to investigate the roles of physiological levels of progesterone and estradiol in "activating" these receptors in terms of permitting oxytocin-induced prostaglandin F-2 alpha release. In long-term ovariectomized cows, treatment with progesterone, but not estradiol, resulted in the induction of responsiveness to oxytocin. This responsiveness appeared within 2 d of progesterone treatment, reached a maximum by 6 d and was maintained to Day 18. In ovariectomized ewes, while estradiol treatment did induce temporary responsiveness to oxytocin after 3 d of treatment, treatment with progesterone was required to induce sustained responsiveness that appeared by Day 9 of treatment and was maintained to Day 12. Measurement of endometrial receptors for oxytocin revealed a significant decline in oxytocin receptors by Day 6 of progesterone treatment when responsiveness to oxytocin was maximal, demonstrating that receptor concentrations were not a limiting factor. The most likely mechanism bywhich progesterone treatment induces responsiveness to oxytocin may be through the up regulation of post receptor signaling pathways and/or enzymes involved in prostaglandin synthesis. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:32:46