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Titolo:
Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo
Autore:
Moyon, D; Pardanaud, L; Yuan, L; Breant, C; Eichmann, A;
Indirizzi:
CNRS, FRE 2160, Inst Embryol Cellulaire & Mol, F-94736 Nogent Sur Marne, France CNRS Nogent Sur Marne France F-94736 l, F-94736 Nogent Sur Marne, France
Titolo Testata:
DEVELOPMENT
fascicolo: 17, volume: 128, anno: 2001,
pagine: 3359 - 3370
SICI:
0950-1991(200109)128:17<3359:POECDA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASES; BLOOD-VESSEL FORMATION; PLACENTA GROWTH FACTOR-2; CARDIOVASCULAR DEVELOPMENT; SEMAPHORIN-III; NERVOUS-SYSTEM; VEIN GRAFTS; FACTOR VEGF; EXPRESSION; NEUROPILIN-1;
Keywords:
neuropilin-1; TIE2; endothelial cell; artery vein; vessel wall; chick-quail chimera;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Eichmann, A CNRS, FRE 2160, Inst Embryol Cellulaire & Mol, 49Bis,Ave BelleGabrielle, F-94736 Nogent Sur Marne, France CNRS 49Bis,Ave Belle GabrielleNogent Sur Marne France F-94736
Citazione:
D. Moyon et al., "Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo", DEVELOPMENT, 128(17), 2001, pp. 3359-3370

Abstract

Remodeling of the primary vascular system of the embryo into arteries and veins has long been thought to depend largely on the influence of hemodynamic forces. This view was recently challenged by the discovery of several molecules specifically expressed by arterial or venous endothelial cells. We here analysed the expression of neuropilin-1 and TIE2, two transmembrane receptors known to play a role in vascular development. In birds, neuropilin-1 was expressed by arterial endothelium and wall cells, but absent from veins. TIE2 was strongly expressed in embryonic veins, but only weakly transcribed in most arteries. To examine whether endothelial cells are committed to an arterial or venous fate once they express these specific receptors, weconstructed quail-chick chimeras. The dorsal aorta, carotid artery and thecardinal and jugular veins were isolated together with the vessel wall from quail embryos between embryonic day 2 to 15 and grafted into the coelom of chick hosts. Until embryonic day 7, all grafts yielded endothelial cells that colonized both host arteries and veins. After embryonic day 7, endothelial plasticity was progressively lost and from embryonic day 11 grafts of arteries yielded endothelial cells that colonized only chick arteries and rarely reached the host veins, while grafts of jugular veins colonized mainly host veins. When isolated from the vessel wall, quail aortic endothelial cells from embryonic day 11 embryos were able to colonize both host arteries and veins. Our results show that despite the expression of arterial or venous markers the endothelium remains plastic with regard to arterial-venousdifferentiation until late in embryonic development and point to a role for the vessel wall in endothelial plasticity and vessel identity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 03:59:45