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Titolo:
The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C-elegans
Autore:
Sarafi-Reinach, TR; Melkman, T; Hobert, O; Sengupta, P;
Indirizzi:
Brandeis Univ, Dept Biol, Waltham, MA 02454 USA Brandeis Univ Waltham MA USA 02454 Univ, Dept Biol, Waltham, MA 02454 USA Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02454 USA Brandeis Univ Waltham MA USA 02454 tr Complex Syst, Waltham, MA 02454 USA Columbia Univ, Ctr Neurobiol & Behav, Dept Biochem & Mol Biophys, New York, NY 10032 USA Columbia Univ New York NY USA 10032 & Mol Biophys, New York, NY 10032 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 17, volume: 128, anno: 2001,
pagine: 3269 - 3281
SICI:
0950-1991(200109)128:17<3269:TLLHGS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEMATODE CAENORHABDITIS-ELEGANS; ODORANT RECEPTOR EXPRESSION; GLR-1 GLUTAMATE-RECEPTOR; VULVAL CELL LINEAGES; SENSORY NEURONS; MOTOR-NEURONS; TRANSCRIPTION FACTORS; CYCLIC NUCLEOTIDE; DROSOPHILA CNS; NERVOUS-SYSTEM;
Keywords:
lin-11; LIM homeobox; Chemosensory neurons; fate specification; Caenorhabditis elegans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Sengupta, P Brandeis Univ, Dept Biol, MS008,415 South St, Waltham, MA 02454 USA Brandeis Univ MS008,415 South St Waltham MA USA 02454 2454 USA
Citazione:
T.R. Sarafi-Reinach et al., "The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C-elegans", DEVELOPMENT, 128(17), 2001, pp. 3269-3281

Abstract

Chemosensory neuron diversity in C. elegans arises from the action of transcription factors that specify different aspects of sensory neuron fate. Inthe AWB and AWA olfactory neurons, the LIM homeobox gene lim-4 and the nuclear hormone receptor gene odr-7 are required to confer AWB and AWA-specific characteristics respectively, and to repress an AWC olfactory neuron-likedefault fate. Here, we show that AWA neuron fate is also regulated by a member of the LIM homeobox gene family, lin-11. lin-11 regulates AWA olfactory neuron differentiation by initiating expression of odr-7, which then autoregulates to maintain expression. lin-11 also regulates the fate of the ASGchemosensory neurons, which are the lineal sisters of the AWA neurons. We show that lin-11 is expressed dynamically in the AWA and ASG neurons, and that misexpression of lin-11 is sufficient to promote an ASG, but not an AWAfate, in a subset of neuron types. Our results suggest that differential temporal regulation of lin-11, presumably together with its interaction withasymmetrically segregated factors, results in the generation of the distinct AWA and ASG sensory neuron types. We propose that a LIM code may be an important contributor to the generation of functional diversity in a subset of olfactory and chemosensory neurons in C. elegans.

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Documento generato il 11/07/20 alle ore 20:50:12