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Titolo:
Successive specification of Drosophila neuroblasts NB 6-4 and NB 7-3 depends on interaction of the segment polarity genes wingless, gooseberry and naked cuticle
Autore:
Deshpande, N; Dittrich, R; Technau, GM; Urban, J;
Indirizzi:
Univ Mainz, Genet Inst, D-55122 Mainz, Germany Univ Mainz Mainz Germany D-55122 inz, Genet Inst, D-55122 Mainz, Germany
Titolo Testata:
DEVELOPMENT
fascicolo: 17, volume: 128, anno: 2001,
pagine: 3253 - 3261
SICI:
0950-1991(200109)128:17<3253:SSODNN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ENGRAILED REGULATION; CELL FATE; NEUROGENESIS; HEDGEHOG; EMBRYOS; MELANOGASTER; EXPRESSION; PATTERN; CNS;
Keywords:
neuroblast; Drosophila; naked cuticle; gooseberry; engrailed; wingless; segment polarity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Urban, J Univ Mainz, Genet Inst, Saarstr 21, D-55122 Mainz, Germany Univ Mainz Saarstr 21 Mainz Germany D-55122 55122 Mainz, Germany
Citazione:
N. Deshpande et al., "Successive specification of Drosophila neuroblasts NB 6-4 and NB 7-3 depends on interaction of the segment polarity genes wingless, gooseberry and naked cuticle", DEVELOPMENT, 128(17), 2001, pp. 3253-3261

Abstract

The Drosophila central nervous system derives from neural precursor cells,the neuroblasts (NBs), which are born from the neuroectoderm by the process of delamination. Each NB has a unique identity, which is revealed by the production of a characteristic cell lineage and a specific set of molecularmarkers it expresses. These NBs delaminate at different but reproducible time points during neurogenesis (S1-S5) and it has been shown for early delaminating NBs (S1/S2) that their identities depend on positional informationconferred by segment polarity genes and dorsoventral patterning genes. We have studied mechanisms leading to the fate specification of a set of late delaminating neuroblasts, NB 6-4 and NB 7-3, both of which arise from the engrailed (en) expression domain, with NB 6-4 delaminating first. In contrast to former reports, we did not find any evidence for a direct role of hedgehog in the process of NB 7-3 specification. Instead, we present evidence to show that the interplay of the segmentation genes naked cuticle (nkd) andgooseberry (gsb), both of which are targets of wingless (wg) activity, leads to differential commitment to NB 6-4 and NB 7-3 cell fate. In the absence of either nkd or gsb, one NB fate is replaced by the other. However, the temporal sequence of delamination is maintained, suggesting that formation and specification of these two NBs are under independent control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 02:24:20