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Titolo:
Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates
Autore:
Murakami, Y; Ogasawara, M; Sugahara, F; Hirano, S; Satoh, N; Kuratani, S;
Indirizzi:
Okayama Univ, Dept Biol, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 iv, Dept Biol, Okayama 7008530, Japan RIKEN, Ctr Dev Biol, Evolut Morphol Res Team, Kobe, Hyogo, Japan RIKEN Kobe Hyogo Japan Biol, Evolut Morphol Res Team, Kobe, Hyogo, Japan Kyoto Univ, Grad Sch Sci, Dept Zool, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 Sch Sci, Dept Zool, Kyoto 6068502, Japan Niigata Univ, Fac Sci, Sch Hlth Sci, Dept Med Technol, Niigata 951, Japan Niigata Univ Niigata Japan 951 Sci, Dept Med Technol, Niigata 951, Japan
Titolo Testata:
DEVELOPMENT
fascicolo: 18, volume: 128, anno: 2001,
pagine: 3521 - 3531
SICI:
0950-1991(200109)128:18<3521:IAEOTL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED BOX GENE; MIDBRAIN-HINDBRAIN BOUNDARY; LAMPETRA-JAPONICA; DEVELOPMENTAL EXPRESSION; NEURAL PLATE; CREST CELLS; CRANIAL NERVES; NERVOUS-SYSTEM; BODY PLAN; SMALL-EYE;
Keywords:
Pax6; lamprey; embryo; neuromeres; forebrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, Y Okayama Univ, Dept Biol, 2-5-1 Shikata Cho, Okayama 7008530, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008530 0, Japan
Citazione:
Y. Murakami et al., "Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates", DEVELOPMENT, 128(18), 2001, pp. 3521-3531

Abstract

The Pax6 gene plays a developmental role in various metazoans as the master regulatory gene for eye patterning. Pax6 is also spatially regulated in particular regions of the neural tube. Because the amphioxus has no neuromeres, an understanding of Pax6 expression in the agnathans is crucial for an insight into the origin of neuromerism in the vertebrates. We have isolateda single cognate cDNA of the Pax6 gene, LjPax6, from a Lampetra japonica cDNA library and observed the pattern of its expression using in situ hybridization. Phylogenetic analysis revealed that LjPax6 occurs as an sister group of gnathostome Pax6. In lamprey embryos, LjPax6 is expressed in the eye,the nasohypophysial plate, the oral ectoderm and the brain. In the centralnervous system, LjPax6 is expressed in clearly delineated domains in the hindbrain, midbrain and forebrain. We compared the pattern of LjPax6 expression with that of other brain-specific regulatory genes, including LjOtxA, LjPax2/5/8, LjDLr1/6, LjEmx and LjTTF1 Most of the gene expression domains showed conserved pattern, which reflects the situation in the gnathostomes, conforming partly to the neuromeric patterns proposed for the gnathostomes. We conclude that most of the segmented domains of the vertebrate brain were already established in the ancestor common to all vertebrates. Major evolutionary changes in the vertebrate brain may have involved local restriction of cell lineages, leading to the establishment of neuromeres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:50:25