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Titolo:
Activity regulates programmed cell death of zebrafish Rohon-Beard neurons
Autore:
Svoboda, KR; Linares, AE; Ribera, AB;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Physiol & Biophys, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Physiol & Biophys, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Program Neurosci, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Program Neurosci, Denver, CO 80262 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 18, volume: 128, anno: 2001,
pagine: 3511 - 3520
SICI:
0950-1991(200109)128:18<3511:ARPCDO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC LATERAL SCLEROSIS; ISTHMO-OPTIC NUCLEUS; DANIO-RERIO; AXONAL SWELLINGS; XENOPUS-LAEVIS; NA+ CHANNELS; SPINAL-CORD; APOPTOSIS; EMBRYO; SURVIVAL;
Keywords:
programmed cell death; Rohon-Beard neurons; zebrafish; neural activity; Na+ current; macho mutant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Ribera, AB Univ Colorado, Hlth Sci Ctr, Dept Physiol & Biophys, 4200 E 9thAve, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262, CO 80262 USA
Citazione:
K.R. Svoboda et al., "Activity regulates programmed cell death of zebrafish Rohon-Beard neurons", DEVELOPMENT, 128(18), 2001, pp. 3511-3520

Abstract

Programmed cell death is a normal aspect of neuronal development. Typically, twice as many neurons are generated than survive. In extreme cases, all neurons within a-population disappear during embryogenesis or by early stages of postnatal development. Examples of transient neuronal populations include Cajal-Retzius cells of the cerebral cortex and Rohon-Beard cells of the spinal cord. The novel mechanisms that lead to such massive cell death have not yet been identified. We provide evidence that electrical activity regulates the cell death program of zebrafish Rohon-Beard cells. Activity was inhibited by reducing Na+ current in Rohon-Beard cells either genetically (the macho mutation) or pharmacologically (tricaine). We examined the effects of activity block on three different reporters of cell death: DNA fragmentation, cytoskeletal rearrangements and cell body loss. Both the mao mutation and pharmacological blockade of Na+ current reduced these signatures of the cell death program. Moreover, the mao mutation and pharmacological blockade of Na+ current produced similar reductions in Rohon-Beard cell death. The results indicate that electrical activity provides signals that are required for the normal elimination of Rohon-Beard cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:23:28