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Titolo:
The immunomodulatory activity of soluble beta-1,3-D-glucan derivatives in piglets after weaning
Autore:
Mucksova, J; Babicek, K; Placerova, I;
Indirizzi:
BIOPHARM, Res Inst Biopharm & Vet Drug AS, Dept Pathol & Microbiol, Jilove25449, Czech Republic BIOPHARM Jilove Czech Republic 25449 robiol, Jilove25449, Czech Republic
Titolo Testata:
CZECH JOURNAL OF ANIMAL SCIENCE
fascicolo: 8, volume: 46, anno: 2001,
pagine: 339 - 347
SICI:
1212-1819(200108)46:8<339:TIAOSB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENHANCED MACROPHAGE FUNCTION; BETA-GLUCAN; MICE; COMPLEMENT; BLOOD;
Keywords:
piglet; carboxymethylglucan; sulfoethylglucan; neutrophil; bactericidal activity; proliferation of peripheral blood monocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Babicek, K BIOPHARM, Res Inst Biopharm & Vet Drug AS, Dept Pathol & Microbiol, Jilove25449, Czech Republic BIOPHARM Jilove Czech Republic 25449 ove25449, Czech Republic
Citazione:
J. Mucksova et al., "The immunomodulatory activity of soluble beta-1,3-D-glucan derivatives in piglets after weaning", CZEC J ANIM, 46(8), 2001, pp. 339-347

Abstract

The effect of intramuscularly administered soluble derivatives of beta -1,3-D-glucan, obtained from the culture filtrate of the yeast Saccharomyces cerevisiae, on the immunological activity of neutrophils and monocytes in piglets after weaning was examined. The single intramuscular administration of carboxymethylglucan at doses 0.5 and 5.0 mg/kg b.w. and sulfoethylglucan at a dose of 0.5 mg/kgb.w. enhanced the reductase activity of neutrophils. The greatest enhancing effect was observed at 0.5 mg/kg b.w. of carboxymethylglucan. Bactericidal activity of peripheral phagocytes and LPS- or PHA-induced proliferation of peripheral blood monocytes were also enhanced after the administration of carboxymethylglucan and sulfoethylglucan by the intramuscular route. These results demonstrate that immunocompetent cells were activated after a single intramuscular administration of all soluble derivatives of beta -1,3-D-glucan tested. It is probable that an adverse influenceof stress on immune functions in animals after weaning may be reduced by the administration of soluble derivatives of beta -1,3-D-glucan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:41:55