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Titolo:
Neuropathic pain
Autore:
Koltzenburg, M; Scadding, J;
Indirizzi:
Univ Coll London, Neurol Inst, London WC1N 1EH, England Univ Coll London London England WC1N 1EH Inst, London WC1N 1EH, England Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 5, volume: 14, anno: 2001,
pagine: 641 - 647
SICI:
1350-7540(200110)14:5<641:NP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; SPINAL NERVE INJURY; ALPHA-LIPOIC ACID; LIDOCAINE PATCH RELIEVES; ACUTE HERPES-ZOSTER; POSTHERPETIC NEURALGIA; DOUBLE-BLIND; DIABETIC POLYNEUROPATHY; PERIPHERAL NEUROPATHY; RECEPTOR ANTAGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Koltzenburg, M Univ Coll London, Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England Univ Coll London 30 Guilford St London England WC1N 1EH nd
Citazione:
M. Koltzenburg e J. Scadding, "Neuropathic pain", CURR OP NEU, 14(5), 2001, pp. 641-647

Abstract

Damage to peripheral nerves triggers a cascade of events in axotomized sensory neurones that are generally believed to be responsible for the generation of neuropathic pain. Recent data in animal models show that alterationsin the properties of undamaged neurones that project into a damaged nerve can also play an important role. These new findings could explain some of the enigmatic clinical signs and symptoms of pain following nerve injury such as the spread of symptoms into areas not affected by the primary lesion. The basis by which uninjured nerves could be affected is a reduced supply of neurotrophic factors, an abnormal interaction in the Remak bundles of partially denervated Schwann cells and unmyelinated axons, or the byproducts of Wallerian degeneration. Curr Opin Neurol 14:641-647. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:28:18