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Titolo:
Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation
Autore:
Martinet, W; Kockx, MM;
Indirizzi:
CATRIMA, Antwerp, Belgium CATRIMA Antwerp BelgiumCATRIMA, Antwerp, Belgium Univ Antwerp, Div Pharmacol, Wilrijk, Belgium Univ Antwerp Wilrijk Belgium v Antwerp, Div Pharmacol, Wilrijk, Belgium
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 535 - 541
SICI:
0957-9672(200110)12:5<535:AIAFOO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; LOW-DENSITY-LIPOPROTEIN; FAS-MEDIATED APOPTOSIS; GENE-EXPRESSION; TISSUE FACTOR; IN-VITRO; PLAQUES; MACROPHAGES; LDL; CHOLESTEROL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Kockx, MM AZ Middelheim, Dept Pathol, Lindendreef 1, B-2000 Antwerp, Belgium AZ Middelheim Lindendreef 1 Antwerp Belgium B-2000 erp, Belgium
Citazione:
W. Martinet e M.M. Kockx, "Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation", CURR OP LIP, 12(5), 2001, pp. 535-541

Abstract

An increasing body of evidence from both animal models and human specimenssuggests that apoptosis or programmed cell death is a major event in the pathophysiology of atherosclerosis. Although the significance of apoptosis in atherosclerosis remains unclear, it has been proposed that apoptotic celldeath contributes to plaque instability, rupture and thrombus formation. Biochemical and genetic analyses of apoptosis provide an increasingly detailed picture of the intracellular signaling pathways involved. Nevertheless, it remains to be determined whether apoptosis can become a clinically important approach to modulate plaque progression. In this review, we have outlined some of the most recent results concerning apoptosis in atherosclerosiswith a special focus on oxidized lipids, inflammation and therapeutic regulation of the apoptotic cell death process. Curr Opin Lipidol 12:535-541., (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:01:36