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Titolo:
Mechanisms of oxysterol-induced apoptosis
Autore:
Panini, SR; Sinensky, MS;
Indirizzi:
E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol,Johnson City, TN 37614 USA E Tennessee State Univ Johnson City TN USA 37614 hnson City, TN 37614 USA
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 529 - 533
SICI:
0957-9672(200110)12:5<529:MOOA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL-CELL APOPTOSIS; SMOOTH-MUSCLE CELLS; CYTOSOLIC PHOSPHOLIPASE A(2); OXIDIZED LDL; CYTOCHROME-C; ATHEROSCLEROTIC PLAQUES; STORE DEPLETION; ACTIVATION; CHOLESTEROL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Sinensky, MS E Tennessee State Univ, James H Quillen Coll Med, Dept Biochem & Mol Biol,Box 70581, Johnson City, TN 37614 USA E Tennessee State Univ Box 70581 Johnson City TN USA 37614 SA
Citazione:
S.R. Panini e M.S. Sinensky, "Mechanisms of oxysterol-induced apoptosis", CURR OP LIP, 12(5), 2001, pp. 529-533

Abstract

The rationale for the present review is that oxysterols found in oxidized LDL (oxLDL) play a role in atherogenesis. This perspective is based on studies that show that induction of apoptosis in vascular cells is an importantprocess in atherogenesis, that apoptosis can be induced by oxLDL, and thatthe oxysterol component of oxLDL is responsible for its proapoptotic activity. The evidence for these concepts is reviewed, as are studies on the mechanisms by which oxysterols can induce apoptosis. An elevation in intracellular calcium appears to be an early signal transduction event that leads toapoptosis through both the extrinsic and intrinsic apoptotic pathways. Curr Coin Lipidol 12:529-533., (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:09:00