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Titolo:
The cellular biology of scavenger receptor class B type I
Autore:
Silver, DL; Tall, AR;
Indirizzi:
Columbia Univ, Dept Med, Div Mol Med, New York, NY 10032 USA Columbia Univ New York NY USA 10032 , Div Mol Med, New York, NY 10032 USA
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 497 - 504
SICI:
0957-9672(200110)12:5<497:TCBOSR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; CHOLESTERYL ESTER HYDROLASE; SELECTIVE LIPID UPTAKE; SR-BI; PLASMA-MEMBRANE; DIETARY-CHOLESTEROL; TARGETED MUTATION; ABC TRANSPORTERS; APICAL DOMAIN; RAT-LIVER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Silver, DL Columbia Univ, Dept Med, Div Mol Med, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ed, New York, NY 10032 USA
Citazione:
D.L. Silver e A.R. Tall, "The cellular biology of scavenger receptor class B type I", CURR OP LIP, 12(5), 2001, pp. 497-504

Abstract

The HDL receptor scavenger receptor class B type I plays an important rolein meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear. In hepatocytes scavenger receptor class B type I mediates the transcytosis of cholesterol into bile, appears to be expressed on both basolateraland apical membranes, and directly interacts with a PDZ domain containing protein that may modulate the activity of scavenger receptor class B type I. This suggests the involvement of scavenger receptor class B type I in higher order complexes in polarized cells. Scavenger receptor class B type I expression has been shown to alter plasma membrane cholesterol distribution and induce the formation of novel membrane structures, suggesting multiple roles for scavenger receptor class B type I in the cell. A close examination of scavenger receptor class B type I function in polarized cells may yield new insights into the mechanism of scavenger receptor class B type I-mediated HDL selective uptake and the effects of scavenger receptor class B type I on cellular cholesterol homeostasis, Curr Opin Lipidol 12:497-504 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:16:07