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Titolo:
Class A scavenger receptors, macrophages, and atherosclerosis
Autore:
Linton, MF; Fazio, S;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA
Titolo Testata:
CURRENT OPINION IN LIPIDOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 489 - 495
SICI:
0957-9672(200110)12:5<489:CASRMA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE CELLS; PROTEIN-KINASE-C; TRANSGENIC MICE; MESSENGER-RNA; CHOLESTEROL DEPOSITION; LESION DEVELOPMENT; OXIDIZED LDL; PPAR-GAMMA; IN-VIVO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Linton, MF Vanderbilt Univ, Sch Med, Dept Cardiovasc Med, 315 Med Res Bldg2, Nashville, TN 37232 USA Vanderbilt Univ 315 Med Res Bldg 2 Nashville TNUSA 37232 2 USA
Citazione:
M.F. Linton e S. Fazio, "Class A scavenger receptors, macrophages, and atherosclerosis", CURR OP LIP, 12(5), 2001, pp. 489-495

Abstract

The scope of this review is to discuss the new advances in our understanding of the role of scavenger receptor class A in the initiation and modulation of the atherosclerotic process. Through the approaches of gene manipulation in the mouse model, a substantial body of literature has accumulated that depicts scavenger receptor class A as a central player in atherogenesis. In studies of scavenger receptor class A overexpression in macrophages through bone marrow transplantation using transgenic donor material, recipientmice with hyperlipidemia caused either by apolipoprotein E or LDL receptordeficiency did not show convincing changes in the degree of atherosclerosis development compared with controls. Conversely, the deletion of the scavenger receptor class A gene in the mouse has shown, in a consistent and significant fashion, that this receptor serves a pro-atherogenic function underhyperlipidemic conditions, as both apolipoprotein E and LDL receptor-deficient mice had reduced atherosclerosis in the absence of scavenger receptor class A. In addition, we have recently shown that C57BL/6 mice are protected from diet-induced atherosclerosis when they lack scavenger receptor classA, and that the macrophage is the cell type responsible for the effect of scavenger receptor class A deficiency in reducing lesion formation in C57BL/6 and LDL receptor null mice. Together, these results demonstrate that macrophage scavenger receptor class A contributes significantly to atherosclerotic lesion formation, and suggest that the uptake of oxidized or modified lipoproteins by vessel wall macrophages is a central process in atherogenesis. Curr Opin Lipidol 12:489-495, (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:24:13