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Titolo:
Targeted delivery of drugs to the gastrointestinal tract
Autore:
Lavelle, EC;
Indirizzi:
Natl Univ Ireland, Dept Biol, Inst Immunol, Maynooth, Kildare, Ireland Natl Univ Ireland Maynooth Kildare Ireland l, Maynooth, Kildare, Ireland Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland
Titolo Testata:
CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS
fascicolo: 4, volume: 18, anno: 2001,
pagine: 341 - 386
SICI:
0743-4863(2001)18:4<341:TDODTT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL M-CELLS; FOLLICLE-ASSOCIATED EPITHELIUM; PATCH M-CELLS; RIBOSOME-INACTIVATING PROTEINS; MUCOSAL IMMUNE-SYSTEM; WHEAT-GERM-AGGLUTININ; LECTIN-MEDIATED BIOADHESION; RAT SMALL-INTESTINE; SECRETORY IMMUNOGLOBULIN-A; PHASEOLUS-VULGARIS LECTINS;
Keywords:
lectin; bioadhesion; drug delivery; gastrointestinal tract; targeting; vaccine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
276
Recensione:
Indirizzi per estratti:
Indirizzo: Lavelle, EC Natl Univ Ireland, Dept Biol, Inst Immunol, Maynooth, Kildare,Ireland Natl Univ Ireland Maynooth Kildare Ireland Kildare, Ireland
Citazione:
E.C. Lavelle, "Targeted delivery of drugs to the gastrointestinal tract", CR R THER, 18(4), 2001, pp. 341-386

Abstract

The oral route is attractive for drug administration because it is associated with patient acceptability, less stringent production conditions, and lower costs. However, gastrointestinal destruction of labile molecules and low levels of absorption generally render oral delivery of peptides and proteins ineffective. Several strategies have the potential to enhance the efficacy of orally administered drugs. Bioadhesion is an approach for increasing interaction between drugs and the mucosae. Bioadhesive systems can be nonspecific, achieving adhesion via mechanical processes or specific systems that recognize receptors on epithelial cells. Lectins are one group of specific bioadhesives with many suitable properties for targeting of cells in the gastrointestinal tract (GIT). This review assesses the potential of lectins in the delivery of drugs and vaccines to the GIT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:13:12