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Titolo:
Nonmyeloablative blood stem cell transplantation as adoptive allogeneic immunotherapy for metastatic renal cell carcinoma
Autore:
Childs, RW;
Indirizzi:
NHLBI, NIH, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CRITICAL REVIEWS IN IMMUNOLOGY
fascicolo: 1-3, volume: 21, anno: 2001,
pagine: 191 - 203
SICI:
1040-8401(2001)21:1-3<191:NBSCTA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; CHRONIC MYELOGENOUS LEUKEMIA; GRAFT-VERSUS-LEUKEMIA; MYELOABLATIVE THERAPY; BREAST-CANCER; HOST DISEASE; CHIMERISM; CHEMOTHERAPY; ENGRAFTMENT; REGRESSION;
Keywords:
nonmyeloablative; NST; renal cell carcinoma; immunotherapy; allogeneic stem cell transplantation; minitransplant; graft-versus-tumor; GVT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Childs, RW NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA NHLBI Bldg 10 Bethesda MD USA 20892 10, Bethesda, MD 20892 USA
Citazione:
R.W. Childs, "Nonmyeloablative blood stem cell transplantation as adoptive allogeneic immunotherapy for metastatic renal cell carcinoma", CR R IMMUN, 21(1-3), 2001, pp. 191-203

Abstract

Allogeneic stem cell transplantation has emerged as a potentially curativeform of immunotherapy for patients with hematological malignancies that are resistant to conventional chemo/radiotherapy. Donor T cell populations targeting allogeneic minor histocompatibility antigens expressed on the patient's malignant cells are felt to be the driving force of the graft-versus-leukemia reaction, although to date only a handful of these antigens have been fully characterized. Recent data from experimental animal models and limited clinical data in humans suggest that graft-versus-tumor effects, analogous to the graft-versus-leukemia reaction, may be generated against malignancies of epithelial origin. This article reviews the results of a pilot trial demonstrating graft-versus-renal cell carcinoma effects following nonmyeloablative stem cell transplantation, highlighting the potential of allogeneic immunotherapy for treating cancer.

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Documento generato il 13/07/20 alle ore 07:58:17