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Titolo:
Role of endogenous endothelin on coronary flow in health and disease
Autore:
Goodwin, AT; Yacoub, MH;
Indirizzi:
Papworth Hosp, Papworth Hosp NHS Trust, Dept Cardiac Surg, Cambridge CB3 8RE, England Papworth Hosp Cambridge England CB3 8RE Surg, Cambridge CB3 8RE, England Harefield Hosp, Heart Sci Ctr, Royal Brompton & Harefield NHS Trust, Dept Cardiac Surg, Harefield, Middx, England Harefield Hosp Harefield Middx England c Surg, Harefield, Middx, England
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 6, volume: 12, anno: 2001,
pagine: 517 - 525
SICI:
0954-6928(200109)12:6<517:ROEEOC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CONGESTIVE-HEART-FAILURE; RECEPTOR ANTAGONIST BOSENTAN; ISCHEMIA-REPERFUSION INJURY; PERFUSED RAT-HEART; NITRIC-OXIDE; BIG ENDOTHELIN-1; INTRACORONARY ENDOTHELIN; CIRCULATING ENDOTHELIN; EARLY ATHEROSCLEROSIS;
Keywords:
endothelin; coronary tone; heart; bosentan; ischaemia; reperfusion; hypertension; heart failure;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Goodwin, AT Papworth Hosp, Papworth Hosp NHS Trust, Dept Cardiac Surg, Cambridge CB3 8RE, England Papworth Hosp Cambridge England CB3 8RE dge CB3 8RE, England
Citazione:
A.T. Goodwin e M.H. Yacoub, "Role of endogenous endothelin on coronary flow in health and disease", CORON ART D, 12(6), 2001, pp. 517-525

Abstract

The role of the endothelium in the control of coronary flow has been demonstrated. Results of recent studies, both on animals and on humans, suggest that endogenous endothelin also plays an important role in basal coronary tone. Disease processes such as ischaemia-reperfusion injury, congestive heart failure, hypertension and atherosclerosis may be contributed to by an imbalance in, or excess of, release of endothelin. With the discovery of newer endothelin antagonists and endothelin converting enzyme inhibitors, especially with fewer hepatic side effects, there is the potential for much future research into novel therapeutic management of these common cardiovascular disorders. Coron Artery Dis 12:517-525 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:18:43