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Titolo:
A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts
Autore:
Ortlepp, JR; Janssens, U; Bleckmann, F; Lauscher, J; Merkelbach-Bruse, S; Hanrath, P; Hoffmann, R;
Indirizzi:
Univ Hosp Aachen, Med Clin 1, D-52057 Aachen, Germany Univ Hosp Aachen Aachen Germany D-52057 Clin 1, D-52057 Aachen, Germany Univ Hosp Aachen, Inst Pathol, D-52057 Aachen, Germany Univ Hosp Aachen Aachen Germany D-52057 Pathol, D-52057 Aachen, Germany
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 6, volume: 12, anno: 2001,
pagine: 493 - 497
SICI:
0954-6928(200109)12:6<493:ACGVIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; ISCHEMIC-HEART-DISEASE; LEFT-VENTRICULAR MASS; HYPERTROPHIC CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; DELETION POLYMORPHISM; CARDIAC-HYPERTROPHY; II FORMATION; SYSTEM; ACE;
Keywords:
atherosclerosis; coronary artery bypass graft; heart chymase; polymorphism; renin-angiotensin-aldosterone system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ortlepp, JR Univ Hosp Aachen, Med Clin 1, Pauwelsstr 30, D-52057 Aachen, Germany Univ Hosp Aachen Pauwelsstr 30 Aachen Germany D-52057 Germany
Citazione:
J.R. Ortlepp et al., "A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts", CORON ART D, 12(6), 2001, pp. 493-497

Abstract

Background Angiotensin II is known to stimulate proliferation of fibroblasts and smooth muscle cells and enhance the atherosclerotic process in native coronary arteries. The impact of genetic polymorphisms of the renin-angiotensin-aldosterone system on coronary bypass graft degeneration is unknown. Methods We examined polymorphisms of four genes (AGTR1, CYP11B2, ACE, CMA)in 101 patients who had follow-up coronary angiography due to symptoms 88 /- 52 months after coronary artery bypass graft surgery. Bypass degeneration was determined with quantitative coronary angiography and an adjusted Gensini score. Results Homozygosity for the G allele of the CMA-1905 polymorphism was associated with a higher degree of bypass degeneration (Bypass Gensini score CMA AA 21.4 +/- 39; AG 24.2 +/- 39.8; GG 27.8 +/- 42.3; NS-time adjusted Gensini bypass scores CMA AA 0.25 +/- 0.68, AG 0.57 +/- 1.82; GG 3.25 +/- 13.2; P=0.005). No association could be detected for the AGTR1, CYP11B2 or ACE polymorphism. Conclusion The CMA allele G is a genetic risk factor for atherosclerosis in venous coronary artery bypass grafts. Its importance has to be shown in further studies. Other polymorphisms of the renin-angiotensin-aldosterone system do not seem to play a role in bypass degeneration. Coron Artery Dis 12:493-497 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:15:32