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Titolo:
Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis
Autore:
Honda, M; Hayashi, K; Matsuda, H; Kubota, E; Tokuyama, H; Okubo, K; Ozawa, Y; Saruta, T;
Indirizzi:
Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 nal Med, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 4, volume: 101, anno: 2001,
pagine: 421 - 427
SICI:
0143-5221(200110)101:4<421:DNAOCC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; NITRIC-OXIDE; PRESSURE-NATRIURESIS; BLOOD-PRESSURE; EXCRETION; BLOCKADE; SYSTEM; MICROCIRCULATION; NORMALIZATION; RESPONSES;
Keywords:
efonidipine; filtration fraction; mibefradil; nifedipine; renal haemodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Saruta, T Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 hinjuku Ku, Tokyo 1608582, Japan
Citazione:
M. Honda et al., "Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis", CLIN SCI, 101(4), 2001, pp. 421-427

Abstract

This study examined the effects of different types of calcium channel antagonists on renal haemodynamics and natriuresis. The intravenous infusion ofnifedipine (L-type blocker), efonidipine (L/T-type blocker) or mibefradil (predominant T-type blocker) into anaesthetized dogs elicited similar, albeit modest, reductions in blood pressure. Nifedipine(1 mug(.)min(-1.)kg(-1))increased renal plasma flow (RPF) (23 +/- 6%; P < 0.05) and glomerular filtration rate (GFR) (25 +/- 5%; P < 0.05) (all values are means +/- S.E.M., n = 7). Efonidipine (0.33 mug(.)min(-1.)kg(-1)) also elevated RPF (18 +/- 6%; P < 0.05), and tended to increase GFR (17 +/- 8%; P = 0.08). These antagonists exerted contrasting actions on the filtration fraction (FF), with anincrease being elicited by nifedipine, whereas efonidipine had no effect. Furthermore, mibefradil (0.01-1 mug(.)min(-1.)kg(-1)) slightly elevated RPF(between 5 +/- 3% and 8 +/- 3%), but failed to alter GFR, resulting in a decrease in FF. Nifedipine slightly increased urinary sodium excretion (UNaV) (29 +/- 16% increase at 1 mug(.)min(-1.)kg(-1)) and fractional sodium excretion (FENa) (18 +/- 14%), whereas efonidipine (0.33 mug(.)min(-1.)kg(-1))elicited marked elevations in UNaV (110 +/- 38%; P < 0.05) and FENa (102 +/- 44%; P < 0.05). Mibefradil (1 mug(.)min(-1.)kg(-1)) exerted a moderate natriuretic action [UNaV, +60 +/- 32% (P = 0.1); FENa, +67 +/- 20% (P < 0.05)]. Furthermore, although a positive correlation was observed between UNaV and urinary nitrate/nitrite excretion, no differences were noted between the various calcium channel antagonists. Collectively, this study demonstrates that the glomerular haemodynamic and natriuretic actions of these calciumchannel antagonists, which possess diverse blocking activities on L/T-typechannels, vary, Based on the divergent actions on FF (i.e. increase, no change and decrease by nifedipine, efonidipine and mibefradil respectively), the natriuretic action of calcium channel antagonists is possibly attributed to the inhibition of tubular sodium reabsorption associated with increased post-glomerular blood flow, rather than increased GFR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:17:14