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Titolo:
Aging alters neuronal nitric oxide release from rat mesenteric arteries: role of presynaptic beta-adrenoceptors
Autore:
Ferrer, M; Balfagon, G;
Indirizzi:
Univ Autonoma Madrid, Fac Med, Dept Fisiol, E-28029 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28029 Fisiol, E-28029 Madrid, Spain
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 4, volume: 101, anno: 2001,
pagine: 321 - 328
SICI:
0143-5221(200110)101:4<321:AANNOR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE RELAXATION; GENE-RELATED PEPTIDE; AGE-RELATED-CHANGES; VASCULAR-RESPONSES; CYCLIC-GMP; MEDIATED RELAXATION; ALPHA-ADRENOCEPTOR; PIAL-ARTERIES; TAIL ARTERY; BLOOD-FLOW;
Keywords:
adrenergic innervation; beta-adrenoceptors; aging; electrical field stimulation; nitrergic innervation; rat mesenteric artery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Balfagon, G Univ Autonoma Madrid, Fac Med, Dept Fisiol, C Arzobispo Morcillo 4, E-28029 Madrid, Spain Univ Autonoma Madrid C Arzobispo Morcillo 4 Madrid Spain E-28029
Citazione:
M. Ferrer e G. Balfagon, "Aging alters neuronal nitric oxide release from rat mesenteric arteries: role of presynaptic beta-adrenoceptors", CLIN SCI, 101(4), 2001, pp. 321-328

Abstract

This study examines the influence of aging on the neuronal nitric oxide (NO) and noradrenaline (NA) release elicited by electrical field stimulation (EFS; 200 mA, 0.3 ms, 1-16 Hz, 30 s) in endothelium-denuded mesenteric arteries from young and old rats, as well as the influence of the presynaptic beta -adrenoceptors in that release, EFS induced frequency-dependent contractions. N-G-nitro-L-arginine methyl ester (L-NAME) only enhanced EFS-elicited contractions in arteries from young rats. Capsaicin did not alter the EFS-induced contractions in either age group. Clenbuterol did not modify the contraction elicited by EFS in arteries from young or old rats either. A subsequent addition of L-NAME also induced an increase in the EFS-induced response in arteries from both age groups. In old rats, the presence of propranolol did not alter the response induced by EFS, and the subsequent additionof clenbuterol or clenbuterol plus L-NAME did not affect this response. Inprecontracted segments, sodium nitroprusside or clenbuterol induced similar relaxation in both age groups. None of the drugs used altered the response to exogenous NA or basal tone. In arteries preincubated with [H-3]NA, EFSinduced H-3 release, which remained unmodified in the presence of clenbuterol or propranolol in young rats, whereas clenbuterol increased the H-3 overflow in old rats, and this effect was abolished by propranolol. These drugs did not alter the basal H-3 efflux and indicate that in rat mesenteric arteries EFS induces NA release in both age groups, and only NO release in young animals. Activation of presynaptic beta -adrenoceptors increased NA andprobably NO release in aged rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:09:57