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Titolo:
Development and validation of a disease extent index for Wegener's granulomatosis
Autore:
de Groot, K; Gross, WL; Herlyn, K; Reinhold-Keller, E;
Indirizzi:
Med Univ Lubeck, Dept Rheumatol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 heumatol, D-23538 Lubeck, Germany Rheumaklin Bad Rappenau, Bad Bramstedt, Germany Rheumaklin Bad Rappenau Bad Bramstedt Germany u, Bad Bramstedt, Germany
Titolo Testata:
CLINICAL NEPHROLOGY
fascicolo: 1, volume: 55, anno: 2001,
pagine: 31 - 38
SICI:
0301-0430(200101)55:1<31:DAVOAD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOPLASMIC ANTIBODY TITER; PULSE CYCLOPHOSPHAMIDE; SYSTEMIC VASCULITIDES; RENAL INVOLVEMENT; CLASSIFICATION; METHOTREXATE; NOMENCLATURE; REMISSION; THERAPY; PHASE;
Keywords:
ANCA-associated vasculitides; disease extent; scoring systems; assessment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: de Groot, K Hannover Med Sch, Nephrol Abt, Carl Neuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
K. de Groot et al., "Development and validation of a disease extent index for Wegener's granulomatosis", CLIN NEPHR, 55(1), 2001, pp. 31-38

Abstract

Aims: The quantitative assessment of disease extent (staging) and activity(grading) in patients with ANCA-associated vasculitides is one prerequisite for the comparison of outcomes in different patient cohorts. We present avalidation study of the Disease Extent Index (DEI). Methods: 66 patients with Wegener's granulomatosis were examined to assess the validity, reliability and sensitivity to change of the DEL Correlation coefficients were calculated to estimate associations between DET and BVAS (Birmingham VasculitisActivity Score), a previously established activity score, and between DEI and serological markers. Results: Among patients with active disease, DEI correlated significantly with cANCA titer (r = 0.46), leukocyte count (r = 0.38) and platelet count (r = 0.53). Among patients in remission, DEI correlated significantly with cANCA titer (r = 0.61), CRP (r = 0.47) and sIL2R (r= 0.47). Additionally, a high association of DEI and BVAS (r = 0.9) confirmed a rather high convergent validity. The effect size of DEI equals 2.37 standard deviation units and indicates a considerable change from active disease to remission. Conclusions: The DEI is valid, reliable, easy, quick to perform and highly reproducible. Although it correlates with some surrogatemarkers of disease activity and the BVAS, the DEI quantifies different domains of the disease than the BVAS and should therefore be used in conjunction with the BVAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:18:10