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Titolo:
Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport
Autore:
Vambutas, A; DeVoti, J; Pinn, W; Steinberg, BM; Bonagura, VR;
Indirizzi:
Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Otolaryngol, New Hyde Pk, NY 11040 USA Albert Einstein Coll Med New Hyde Pk NY USA 11040 w Hyde Pk, NY 11040 USA Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Pediat, Div Allergy & Immunol, New Hyde Pk, NY 11040 USA Albert Einstein Coll Med New Hyde Pk NY USA 11040 w Hyde Pk, NY 11040 USA Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Internal Med, New Hyde Pk, NY 11040 USA Albert Einstein Coll Med New Hyde Pk NY USA 11040 w Hyde Pk, NY 11040 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 101, anno: 2001,
pagine: 94 - 99
SICI:
1521-6616(200110)101:1<94:IOHPT1>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; LARYNGEAL PAPILLOMA; EXPRESSION; CELLS; COMPLEX; DIFFERENTIATION; TAPASIN; GENE; CTL;
Keywords:
human; transporters; antigen presentation; infectious immunity-virus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Vambutas, A Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Otolaryngol, Long Isl Campus, New Hyde Pk, NY 11040 USA Albert Einstein Coll Med Long Isl Campus New Hyde Pk NY USA 11040
Citazione:
A. Vambutas et al., "Interaction of human papillomavirus type 11 E7 protein with TAP-1 results in the reduction of ATP-dependent peptide transport", CLIN IMMUNO, 101(1), 2001, pp. 94-99

Abstract

Human papillomaviruses (HPVs) cause benign and malignant epithelial tumorsof the respiratory and genital mucosa. We previously reported that recurrent respiratory papillomas caused by HPV 6/11 express low levels of antibody-detectable TAP-1, the protein that transports peptides into the endoplasmic reticulum for assembly and presentation by MHC Class I, and that the extent of TAP-1 immunostaining is inversely related to the frequency of diseaserecurrence. We have now determined a mechanism for the reduction in TAP-I detection. Anti-TAP-1 antibody immunoprecipitated very low amounts of protein from papilloma cells. However, immunoprecipitation of calreticulin, another member of the MHC I assembly complex, coprecipitated TAP-I at levels comparable to those of uninfected cells. Immunoprecipitation of an HPV-positive cell line with either anti-TAP-1 or anti-calreticulin coprecipitated HPVE7 protein. Finally, purified HPV 11 E7 protein inhibited ATP-dependent peptide transport in vitro. We propose that the interaction of E7 with TAP-I prevents TAP-I antibody detection and efficient peptide transport, resulting in poor presentation of viral antigen on HPV-infected cells and thus failure to mount an effective immune-mediated prevention of disease recurrence. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:36:23