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Titolo:
Analysis of monocyte chemotactic protein-1 production in different major histocompatability complex-restricted antigen presentation systems
Autore:
Tekstra, J; Tjin, EPM; Tuk, CW; Broekhuis-Fluitsma, D; Havenith, CEG; Beelen, RHJ;
Indirizzi:
Vrije Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 101, anno: 2001,
pagine: 77 - 85
SICI:
1521-6616(200110)101:1<77:AOMCPP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE RECRUITMENT; CELLULAR-POLARIZATION; PERITONEAL-DIALYSIS; DENDRITIC CELLS; CHEMOKINES; CYTOKINES; ACTIVATION; MACROPHAGES;
Keywords:
MCP-1 production; antigen presentation; NMC restriction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Tekstra, J Vrije Univ Amsterdam, Fac Med, Dept Cell Biol & Immunol, van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
J. Tekstra et al., "Analysis of monocyte chemotactic protein-1 production in different major histocompatability complex-restricted antigen presentation systems", CLIN IMMUNO, 101(1), 2001, pp. 77-85

Abstract

In the present study the production of the CC chemokine monocyte chemotactic protein-1 (MCP-1) in several NMC II-restricted antigen presentation systems was investigated in vitro. To assess which type of antigen-presenting cell (APC) influences MCP-1 production during antigen presentation, culturesenriched for different APC populations were prepared and MCP-1 production was determined. Our results showed that APCs that effectively induce a T cell response also produce elevated amounts of MCP-1. The MCP-1 production ishighest in the memory-driven secondary response against a single antigen. Despite a massive T cell proliferation, low MCP-1 concentrations are found in Con A-induced cultures. These results suggest that T cell proliferation alone is not sufficient for MCP-1 production and that stimulation of the APC during the process of antigen presentation results in MCP-1 production. Based on our results and the literature, we propose a model for MCP-1 as an enhancer of the adaptive immune response. (C) 2001 Academic Press.

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Documento generato il 07/04/20 alle ore 22:51:10