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Titolo:
Cryoprecipitate of patients with cryoglobulinemic glomerulonephritis contains molecules of the lectin complement pathway
Autore:
Ohsawa, I; Ohi, H; Tamano, M; Endo, M; Fujita, T; Satomura, A; Hidaka, M; Fuke, Y; Matsushita, M; Fujita, T;
Indirizzi:
Nihon Univ, Sch Med, Tokyo, Japan Nihon Univ Tokyo JapanNihon Univ, Sch Med, Tokyo, Japan Fukushima Med Univ, Sch Med, Dept Biochem, Fukushima, Japan Fukushima Med Univ Fukushima Japan Med, Dept Biochem, Fukushima, Japan
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 101, anno: 2001,
pagine: 59 - 66
SICI:
1521-6616(200110)101:1<59:COPWCG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE-BINDING-PROTEIN; HEPATITIS-C VIRUS; MIXED CRYOGLOBULINEMIA; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; SERINE-PROTEASE; GLOMERULAR DEPOSITION; ACTIVATION; INFECTION; SERUM; GENE;
Keywords:
cryoglobulinemia; cryoglobulinemia glomerulonephritis; cryoglobulin; hepatitis C virus (HCV); lectin pathway; mannose-binding lectin (MBL); MBL-associated serine protease (MASP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ohsawa, I Nihon Univ, Sch Med, Tokyo, Japan Nihon Univ Tokyo JapanNihon Univ, Sch Med, Tokyo, Japan
Citazione:
I. Ohsawa et al., "Cryoprecipitate of patients with cryoglobulinemic glomerulonephritis contains molecules of the lectin complement pathway", CLIN IMMUNO, 101(1), 2001, pp. 59-66

Abstract

Serological and histological studies were carried out to explore the role of the lectin complement pathway in the pathogenesis of cryoglobulinemic glomerulonephritis. Sixteen patients with mixed cryoglobulinemia type II withglomerulonephritis (GN) were enrolled. All cases had hepatitis C virus (HCV) infection. The serum concentration of mannose-binding lectin (MBL) was significantly higher in the GN patients than in the normal controls according to ELISA (P<0.01). IgG, IgM, C1q, C4d, HCV envelope antigen, MBL, and MBL-associated serine protease-1 (MASP-1) could be visualized in the cryoprecipitate of the 16 patients by Dot blot assay. Renal biopsy specimens obtained from 3 patients were examined by immunohistochemistry, and the glomeruli strongly stained for IgG, IgM, MBL, MASP-1, C4d, C3c, and C3d in a fringe-like pattern. The pattern of HCV constituent deposition was partially fringe-like. The complement profiles of the 16 cases were distinctive; briefly, the serum levels of C1q, C2, and C3 were reduced, although the levels of circulating regulatory proteins (C1-inhibitor, factor, H, and factor I) were in the normal range. The serum C4 level was significantly reduced. These results indicate that immune complex formation involves molecules of the lectin pathway and leads to organ damage in cryoglobulinemic glomerulonephritis. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 15:09:38