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Titolo:
Fibrillarin and other snoRNP proteins are targets of autoantibodies in xenobiotic-induced autoimmunity
Autore:
Yang, JM; Baserga, SJ; Turley, SJ; Pollard, KM;
Indirizzi:
Scripps Clin & Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 Med, La Jolla, CA 92037 USA Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 herapeut Radiol, New Haven, CT 06520 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 101, anno: 2001,
pagine: 38 - 50
SICI:
1521-6616(200110)101:1<38:FAOSPA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL NUCLEOLAR RIBONUCLEOPROTEIN; RNA-BINDING PROTEINS; RIBOSOMAL-RNA; COILED BODY; ANTINUCLEOLAR ANTIBODIES; MURINE SUSCEPTIBILITY; PRENUCLEOLAR BODIES; MOLECULAR-CLONING; IMMUNE DEPOSITS; HUMAN-DISEASE;
Keywords:
snoRNP; fibrillarin; mercury; Cajal body; monoclonal antibody; murine; autoantibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, JM Scripps Clin & Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA Scripps Clin & Res Inst La Jolla CA USA 92037 olla, CA 92037 USA
Citazione:
J.M. Yang et al., "Fibrillarin and other snoRNP proteins are targets of autoantibodies in xenobiotic-induced autoimmunity", CLIN IMMUNO, 101(1), 2001, pp. 38-50

Abstract

Exposure of SJL/J mice to mercury induces an antinucleolar autoantibody response. The predominant target is fibrillarin, a 34-kDa component of the small nucleolar ribonucleoprotein particles (snoRNP), but other proteins are also recognized. To characterize these proteins, monoclonal IgG anti-nucleolar antibodies were produced from HgC1(2)-treated SJL/J mice. One monoclonal, 17C12, recognized fibrillarin, while two others, 7G3 and 6G10, were found to immunoprecipitate snoRNP particles but not fibrillarin. Antibody 6G10 gave a nucleolar immunofluorescence pattern in human, murine, and amphibiancells, but was negative in immunoblot. The 7G3 monoclone reacted with a 60-kDa protein conserved in human and murine, but not amphibian, cell lines. The 7G3 and 6G10 antigens and fibrillarin colocalized to the nucleolus and Cajal bodies in interphase cells and decorated metaphase chromosomes. Thesestudies suggest that the mercury-induced anti-nucleolar antibody response targets other protein components of the snoRNP particles in addition to fibrillarin. (C) 2001 Academic Press.

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Documento generato il 01/10/20 alle ore 16:06:25