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Titolo:
Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer
Autore:
Shibahara, K; Sugio, K; Osaki, T; Uchiumi, T; Maehara, Y; Kohno, K; Yasumoto, K; Sugimachi, K; Kuwano, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 pt Med Biochem, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Surg, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Surg, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Sci, Fukuoka 8128582, Japan Univ Occupat & Environm Hlth, Dept Surg 2, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Dept Mol Biol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 10, volume: 7, anno: 2001,
pagine: 3151 - 3155
SICI:
1078-0432(200110)7:10<3151:NEOTYB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; DNA; IRRADIATION; ACTIVATION; CISPLATIN; FAMILY; LIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kuwano, M Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, 3-1-1 Maidashi,Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 8128582, Japan
Citazione:
K. Shibahara et al., "Nuclear expression of the Y-box binding protein, YB-1, as a novel marker of disease progression in non-small cell lung cancer", CLIN CANC R, 7(10), 2001, pp. 3151-3155

Abstract

Transcription factor Y-box binding protein I (YB-1) that binds to the nverted CCAAT box Is involved not only in transcription of various genes but also in cell proliferation and DNA repair. We determined whether localizationof YB-1 in either the nucleus or cytoplasm could serve as a prognostic marker for patients with non-small cell lung cancer (NSCLC). In 196 NSCLC patients, expression of YB-1 protein in the nucleus or cytoplasm was immunohistochemically evaluated. Of the 196 tumors examined, 88 (44.9%) were positivefor YB-1 expression in the nucleus. Nuclear YB-I expression significantly correlated with T factor, lymph node metastasis, and stage of the disease. Patients with a nuclear YB-1 tumor had a poorer prognosis than did those with a cytoplasmic YB-1 tumor in all of the NSCLC patients (P = 0.0494) and in patients with squamous cell carcinoma (P = 0.0313) but not in patients with adenocarcinomas. Nuclear localization of the YB-l protein may prove to be an important factor of disease progression for patients with NSCLC, in particular, in cases of squamous cell carcinoma.

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Documento generato il 11/07/20 alle ore 19:24:45